Results 31 to 40 of about 6,523 (214)

Alloimmune T cells in transplantation [PDF]

Journal of Clinical Investigation, 2017
Alloimmune T cells are central mediators of rejection and graft-versus-host disease in both solid organ and hematopoietic stem cell transplantation. Unique among immune responses in terms of its strength and diversity, the T cell alloresponse reflects extensive genetic polymorphisms between allogeneic donors and recipients, most prominently within the ...
Megan Sykes, Susan DeWolf
openaire   +3 more sources

Altered type 1 interferon responses in alloimmunized and nonalloimmunized patients with sickle cell disease

eJHaem, 2021
Patients with sickle cell disease (SCD) have a high prevalence of RBC alloimmunization. However, underlying mechanisms are poorly understood. Given that proinflammatory type 1 interferons (IFNα/β) and interferon stimulated genes (ISGs) promote ...
Emaan Madany, June Lee, Chelsea Halprin, Jina Seo, Nicole Baca, Fataneh Majlessipour, Jeanne E. Hendrickson, Samuel H. Pepkowitz, Chelsea Hayes, Ellen Klapper, David R. Gibb   +10 more
doaj   +1 more source

The rejection that defies anti-rejection drugs. Chronic vascular rejection (allograft vasculopathy): The role of terminology and linguistic relativity [PDF]

arXiv, 2023
Solid organ transplantation has by now become a common medical procedure. Owing to the introduction of new immunosuppressive drugs, the allograft loss due to acute rejection has been reduced significantly over time. Tragically, the number of donor organs lost due to allograft vasculopathy (AV), generally named chronic vascular rejection or chronic ...
arxiv  

Current status of alloimmunity [PDF]

Current Opinion in Nephrology and Hypertension, 2016
The present review aims to highlight the major recent advances in transplantation with regards to basic, translational, and clinical research.We describe new concepts in understanding allorecognition and allospecificity of T cells, and discuss current challenges in targeting memory T cells, including the limitation of rodent disease models.
Naoka Murakami, Thiago J. Borges, Leonardo V. Riella   +2 more
openaire   +3 more sources

Alloimmunization in multitransfused liver disease patients: Impact of underlying disease

Asian Journal of Transfusion Science, 2016
Introduction: Transfusion support is vital to the management of patients with liver diseases. Repeated transfusions are associated with many risks such as transfusion-transmitted infection, transfusion immunomodulation, and alloimmunization.
Meenu Bajpai, Shruti Gupta, Priyanka Jain   +2 more
doaj   +1 more source

Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use

American Journal of Perinatology Reports, 2016
Objectives The objective is to present a pregnancy complication associated with intravenous drug use, namely, that of red blood cell alloimmunization and hemolytic disease of the fetus and newborn.
Kara B. Markham, Scott R. Scrape, Mona Prasad, Karen Q. Rossi, Richard W. O'Shaughnessy   +4 more
doaj   +1 more source

Treatments for hematologic malignancies in contrast to those for solid cancers are associated with reduced red cell alloimmunization

Haematologica, 2017
Red cell alloimmunization may induce severe hemolytic side effects. Identification of risk-modifying conditions will help tailor preventative strategies.
Dorothea Evers, Jaap Jan Zwaginga, Janneke Tijmensen, Rutger A. Middelburg, Masja de Haas, Karen M.K. de Vooght, Daan van de Kerkhof, Otto Visser, Nathalie C.V. Péquériaux, Francisca Hudig, Johanna G. van der Bom   +10 more
doaj   +1 more source

TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA.

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Context and Objectives: Blood transfusions (BT) remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. We aim to assess infectious markers, red cell alloimmunization and iron overload secondary
Moussa Seck, Alioune Badara Senghor, Mossane Loum, Sokhna Aissatou Touré, Blaise Félix Faye, Alioune Badara Diallo, Mohamed Keita, Elimane Seydi Bousso, Sérigne Mourtalla Guèye, Macoura Gadji, Abibatou Sall, Awa Oumar Touré, Saliou Diop   +12 more
doaj   +1 more source

Allopeptides and the alloimmune response [PDF]

Cellular Immunology, 2007
The inherent ability of the host immune system to distinguish between self- and non-self forms the basis of allorecognition. T lymphocytes constitute the most important effector arm of allorecognition. Here we describe the fundamentals of direct and indirect pathways by which allopeptides are presented to effector T cells.
T. Mohanakumar, Ankit Bharat
openaire   +3 more sources

Red cell alloimmunization is associated with development of autoantibodies and increased red cell transfusion requirements in myelodysplastic syndrome

Haematologica, 2017
Up to 90% of patients with a myelodysplastic syndrome require red blood cell transfusion; nevertheless, comprehensive data on red cell alloimmunization in such patients are limited.
Deepak Singhal, Monika M. Kutyna, Rakchha Chhetri, Li Yan A. Wee, Sophia Hague, Lakshmi Nath, Shriram V. Nath, Romi Sinha, Nicholas Wickham, Ian D. Lewis, David M. Ross, Peter G. Bardy, Luen Bik To, John Reynolds, Erica M. Wood, David J. Roxby, Devendra K. Hiwase   +16 more
doaj   +1 more source