Results 41 to 50 of about 10,210 (217)

Alloimmunization in multitransfused liver disease patients: Impact of underlying disease

Asian Journal of Transfusion Science, 2016
Introduction: Transfusion support is vital to the management of patients with liver diseases. Repeated transfusions are associated with many risks such as transfusion-transmitted infection, transfusion immunomodulation, and alloimmunization.
Meenu Bajpai, Shruti Gupta, Priyanka Jain   +2 more
doaj   +1 more source

Routine Fetal Rhd Genotyping with Maternal Plasma: A Four-Year Experience in Belgium [PDF]

, 2008
peer reviewedBACKGROUND: The objective was to evaluate the diagnostic value of RHD fetal genotyping from the plasma of D- mothers as soon as 10 weeks' gestation in a routine clinical practice in Belgium.
Bianchi DW, Colin Y, Cortey A, Daniels G, Flegel WA, Flegel WA, Grootkerk MG, Judd WJ, Legler J, Mannessier L, Minon JM, Moise KJ, Moise KJ, Singleton BK, Wagner FF, Wagner FF   +15 more
core   +1 more source

TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA.

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Context and Objectives: Blood transfusions (BT) remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. We aim to assess infectious markers, red cell alloimmunization and iron overload secondary
Moussa Seck, Alioune Badara Senghor, Mossane Loum, Sokhna Aissatou Touré, Blaise Félix Faye, Alioune Badara Diallo, Mohamed Keita, Elimane Seydi Bousso, Sérigne Mourtalla Guèye, Macoura Gadji, Abibatou Sall, Awa Oumar Touré, Saliou Diop   +12 more
doaj   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Risk factors for alloimmunization by patients with sickle cell disease

Brazilian Journal of Medical and Biological Research, 2005
Blood transfusion in patients with sickle cell disease (SCD) is limited by the development of alloantibodies to erythrocytes. In the present study, the frequency and risk factors for alloimmunization were determined.
M. Murao, M.B. Viana
doaj   +1 more source

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, EarlyView.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

RhD alloimmunization – diagnostics, therapy and prophylaxis

Quality in Sport
Introduction: The success in preventing and treating Rh D alloimmunization is a major accomplishment in modern obstetrics. The widespread use of Rh D immune globulin has led to a decline in red cell alloimmunization.
Radoslaw Ciesielski, Anna Mich, Klaudia Perkowska, Anna Kaźmierczak, Wiktoria Izdebska, Patrycja Sornek, Anna Kiełb, Igor Pawlak, Jakub Stanek, Agata Borkowska   +9 more
doaj   +1 more source

Red cell alloimmunization is associated with development of autoantibodies and increased red cell transfusion requirements in myelodysplastic syndrome

Haematologica, 2017
Up to 90% of patients with a myelodysplastic syndrome require red blood cell transfusion; nevertheless, comprehensive data on red cell alloimmunization in such patients are limited.
Deepak Singhal, Monika M. Kutyna, Rakchha Chhetri, Li Yan A. Wee, Sophia Hague, Lakshmi Nath, Shriram V. Nath, Romi Sinha, Nicholas Wickham, Ian D. Lewis, David M. Ross, Peter G. Bardy, Luen Bik To, John Reynolds, Erica M. Wood, David J. Roxby, Devendra K. Hiwase   +16 more
doaj   +1 more source

Hemolytic Disease of the Fetus and Newborn: Fetal RHD Genotyping, Targeted Prophylaxis, and Prenatal Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup, Steffen Thorsen, Morten Hanefeld Dziegiel, Olav Bjørn Petersen, Frederik Banch Clausen   +4 more
wiley   +1 more source

Rh Negative Status and Isoimmunization Update: A Case-Based Approach to Care [PDF]

, 2003
Prior to the 1970s and the advent of Rho (D) immune globulin (RIG) for Rh negative women, hemolytic disease of the newborn led to morbidity, long-term disabilities, and mortality.
Hanson, Lisa, Harrod, Kathryn Shisler, Heywood, Patricia, VandeVusse, Leona   +3 more
core   +1 more source