Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands [PDF]
, 2019 The synaptic α1β2γ2 ...
Akk, Gustav +5 more
core +1 more source
Disadaptive disorders in women: allopregnanolone, a sensitive steroid
Gynecological Endocrinology, 2004 Allopregnanolone, a neurosteroid acting as a potent anxiolytic agonist of the gamma-aminobutyric acid A receptor, has been shown in animal models to modify its concentrations at central and peripheral levels according to the estrous cycle. Moreover, it modulates behavioral and biochemical responses to acute and chronic stress, anxiety, depression ...
Bernardi F +6 more
openaire +3 more sources
The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]
, 2019 Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Webster, Corey Michael
core
Allopregnanolone involvement in feeding regulation, overeating and obesity
Frontiers in Neuroendocrinology, 2018 Obesity is strongly associated with ill health, primarily caused by consumption of excessive calories, and promoted (inter alia) by gamma-amino-butyric-acid (GABA) stimulating food intake by activating GABAA receptors (primarily with α3 and α2 subunits) in the hypothalamic arcuate nucleus and paraventricular nucleus.
Holmberg, Ellinor +10 more
openaire +3 more sources
A Rationale for Allopregnanolone Treatment of Alcohol Use Disorders: Basic and Clinical Studies.
Alcoholism: Clinical and Experimental Research, 2019 For many years, research from around the world has suggested that the neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone or 3α,5α-THP) may have therapeutic potential for treatment of various symptoms of alcohol use disorders (AUDs). In
A. Morrow, Giorgia Boero, P. Porcu
semanticscholar +1 more source
The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause.
Psychoneuroendocrinology, 2019 The neuroactive steroid 3α-5α-tetrahydroprogesterone (allopregnanolone), a metabolite of progesterone, is a positive allosteric modulator of GABAA receptors, and low levels have been implicated in the etiology of mood disorders.
Allison Kimball +16 more
semanticscholar +1 more source
Chronic Stress, 2018 Allopregnanolone and pregnanolone—neurosteroids synthesized from progesterone in the brain, adrenal gland, ovary and testis—have been implicated in a range of neuropsychiatric conditions including seizure disorders, post-traumatic stress disorder, major ...
Jennifer J. Liang, Ann M. Rasmusson
doaj +1 more source
4512 Allopregnanolone Dose Finding for Status Epilepticus Treatment by Pharmacokinetic-Pharmacodynamic Modeling using Quantitative EEG in Dogs [PDF]
, 2020 Edward N. Patterson +7 more
openalex +1 more source
Allopregnanolone and Pentobarbital Infused Into the Nucleus Accumbens Substitute for the Discriminative Stimulus Effects of Ethanol [PDF]
, 2001 Clyde W. Hodge +4 more
openalex +1 more source