Results 71 to 80 of about 61,179 (292)

Comparative cardiovascular risk in users versus non-users of xanthine oxidase inhibitors and febuxostat versus allopurinol users.

Rheumatology, 2019
OBJECTIVES The aim of this study is to determine major adverse cardiovascular events (MACE) and all-cause mortality comparing between xanthine oxidase inhibitors (XOIs) and non-XOI users, and between allopurinol and febuxostat.
Chengsheng Ju, R. W. Lai, K. H. C. Li, Joshua Kai Fung Hung, J. Lai, J. Ho, Yingzhi Liu, M. Tsoi, Tong Liu, B. Cheung, I. Wong, L. Tam, G. Tse   +12 more
semanticscholar   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Follow-up monitoring in a cat with leishmaniosis and coinfections with Hepatozoon felis and ‘Candidatus Mycoplasma haemominutum’ [PDF]

, 2017
Case summary A 6-year-old female neutered domestic shorthair cat from Cyprus was presented with multiple ulcerated skin nodules. Cytology and histopathology of the lesions revealed granulomatous dermatitis with intracytoplasmic organisms, consistent ...
Attipa, C, Baneth, G, Brooks-Brownlie, H, Martínez-Orellana, P, Nachum-Biala, Y, Neofytou, K, Solano-Gallego, L, Tasker, S, Yiapanis, C   +8 more
core   +6 more sources

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine, EarlyView.
This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
wiley   +1 more source

Chronic allopurinol treatment during the last trimester of pregnancy in sows: effects on low and normal birth weight offspring. [PDF]

PLoS ONE, 2014
Low-birth-weight (LBW) children are born with several risk factors for disease, morbidity and neonatal mortality, even if carried to term. Placental insufficiency leading to hypoxemia and reduced nutritional supply is the main cause for LBW. Brain damage
Elise T Gieling, Alexandra Antonides, Johanna Fink-Gremmels, Kim Ter Haar, Wikke I Kuller, Ellen Meijer, Rebecca E Nordquist, Jacomijn M Stouten, Elly Zeinstra, Franz Josef van der Staay   +9 more
doaj   +1 more source

Establishment of a novel cynomolgus monkey model of hyperuricemia

Animal Models and Experimental Medicine, EarlyView.
We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang, Le Zhang, Can Yang, Guan‐Cong Luo, Rui‐Chang Liu, Yan‐Jun Xu, Sheng Cheng, Wen‐Yu Jiang, Richard Ward, Yang Yang, Cheng Xiang, Shu An, Tian‐Rui Xu   +12 more
wiley   +1 more source

Does Allopurinol Prevent Post Endoscopic Retrograde Cholangio- Pancreatography Pancreatitis? A Randomized Double Blind Trial [PDF]

Acta Medica Iranica, 2011
Post endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a frequent complication either for diagnosis or treatment of pancreatobiliary diseases.
Mohammad Abbasinazari, Amir Houshang Mohammad Alizadeh, Kamyar Moshiri, Mohammad Amin Pourhoseingholi, Mohammad Reza Zali   +4 more
doaj   +1 more source

Allopurinol Suppresses Azoxymethane-Induced Colorectal Tumorigenesis in C57BL/KsJ-db/db Mice

Gastrointestinal Disorders, 2020
Obesity and related metabolic disorders, including chronic inflammation and enhanced oxidative stress, are closely associated with the development and progression of colorectal cancer.
Junichi Kato, Yohei Shirakami, Kimihiro Yamaguchi, Taku Mizutani, Takayasu Ideta, Hiroshi Nakamura, Soranobu Ninomiya, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Takuji Tanaka, Masahito Shimizu   +11 more
doaj   +1 more source

Allopurinol therapy in gout patients does not associate with beneficial cardiovascular outcomes: a population-based matched-cohort study. [PDF]

PLoS ONE, 2014
Previous studies have shown an association between gout and/or hyperuricemia and a subsequent increase in cardiovascular disease (CVD) outcomes. Allopurinol reduces vascular oxidative stress, ameliorates inflammatory state, improves endothelial function,
Victor C Kok, Jorng-Tzong Horng, Wan-Shan Chang, Ya-Fang Hong, Tzu-Hao Chang   +4 more
doaj   +1 more source

Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

BMC Pediatrics, 2019
BackgroundPerinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even more in regions with lower level of
C. Maiwald, K. Annink, M. Rüdiger, M. Benders, F. van Bel, K. Allegaert, G. Naulaers, D. Bassler, Katrin Klebermaß-Schrehof, M. Vento, H. Guimarães, T. Stiris, L. Cattarossi, M. Metsäranta, S. Vanhatalo, J. Mazela, T. Metsvaht, Y. Jacobs, A. Franz   +18 more
semanticscholar   +1 more source