Results 91 to 100 of about 3,437 (186)

Positional cloning of the allorecognition gene alr1 in the cnidarian Hydractinia symbiolongicarpus

, 2010
Allorecognition, defined as the ability to discriminate between self and non-self, is ubiquitous to colonial metazoans and widespread in aclonal taxa. Invertebrate allorecognition phenomena are of broad interest and have long captured the attention of ...
Rosa, Sabrina
core  

Implications of MHC-restricted immunopeptidome in transplantation

Frontiers in Immunology
The peptide presentation by donor and recipient major histocompatibility complex (MHC) molecules is the major driver of T-cell responses in transplantation.
Zhuldyz Zhanzak, Zhuldyz Zhanzak, Davide Cina, Davide Cina, Aileen C. Johnson, Aileen C. Johnson, Christian P. Larsen, Christian P. Larsen   +7 more
doaj   +1 more source

Allogeneic HLA Humoral Immunogenicity and the Prediction of Donor-Specific HLA Antibody Development

Antibodies
The development of de novo donor-specific HLA antibodies (dnDSAs) following solid organ transplantation is considered a major risk factor for poor long-term allograft outcomes.
Vadim Jucaud
doaj   +1 more source

Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells

Frontiers in Transplantation
Mass Spectrometry allied with in-vivo generation of activated alloreactive T cell populations and tetramer screening facilitates the identification of endogenous peptides that are directly recognised in complex with allogeneic Major Histocompatibility ...
Alexandra E. Hill, Eric T. Son, Moumita Paul-Heng, Chuanmin Wang, Shivanjali Ratnaseelan, Martina Denkova, Pouya Faridi, Asolina Braun, Anthony W. Purcell, Nicole A. Mifsud, Alexandra F. Sharland   +10 more
doaj   +1 more source

Mixed Lymphocyte Reaction: Functional Immune Profiling in Transplantation and Beyond

Diagnostics
The mixed lymphocyte reaction (MLR) is a classic functional assay that models in vitro interactions between responder T cells and allogeneic antigen-presenting cells (APCs).
Nurtilek Galimov, Aruzhan Asanova, Sholpan Altynova, Aidos Bolatov   +3 more
doaj   +1 more source

AATF Genome: Evolution of Allorecognition

, 2015
International audienceHuman AATF genome holds AATF gene and its encoded miR-2909 in its fold, toexhibit “Hysteresis phenomenon” arising out of bi-stable cooperative-activityof these AATF gene-products.
Deepak Kaul, Kaul, Deepak
core   +1 more source

A library-based examination of T cell allorecognition 2259104

Introduction Alloreactive T cells drive acute transplant rejection and Graft-versus-Host-Disease (GvHD) by reacting to peptides displayed on non-self MHC (allo-MHC).
Michael Birnbaum, Amanda Chan, Rachit Mukkamala, Stephanie Gaglione   +3 more
core   +1 more source

The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum

Nature Communications
Greenbeard genetic elements encode rare perceptible signals, signal recognition ability, and altruism towards others that display the same signal. Putative greenbeards have been described in various organisms but direct evidence for all the properties in
Mariko Katoh-Kurasawa, Peter Lehmann, Gad Shaulsky   +2 more
doaj   +1 more source

Emergence and evolution of Botryllus schlosseri allorecognition genes

Sessile colonial marine invertebrates can experience a natural histocompatibility process similar to tissue and organ transplantation observed in humans.
Rodriguez, Henry Jose
core   +1 more source

het-B allorecognition in Podospora anserina is determined by pseudo-allelic interaction of genes encoding a HET and lectin fold domain protein and a PII-like protein.

PLoS Genetics
Filamentous fungi display allorecognition genes that trigger regulated cell death (RCD) when strains of unlike genotype fuse. Podospora anserina is one of several model species for the study of this allorecognition process termed heterokaryon or ...
Corinne Clavé, Sonia Dheur, Sandra Lorena Ament-Velásquez, Alexandra Granger-Farbos, Sven J Saupe   +4 more
doaj   +1 more source