Results 191 to 200 of about 63,430 (242)

Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights

ChemistryOpen, EarlyView.
The study investigates the sedative potential of naringenin (NAR) through in vivo and in silico approaches. NAR significantly enhances sleep duration and reduces latency in mice, especially when combined with diazepam. Molecular docking shows strong binding to GABAA receptors, suggesting a GABAergic mechanism.
Dipu Bishwas, Md. Shimul Bhuia, Salehin Sheikh, Mohammed Alfaifi, Abdul Malik, Nikhat J. Siddiqui, Divya Jain, Mehedi Hasan Bappi, Muhammad Torequl Islam   +8 more
wiley   +1 more source

A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling. [PDF]

Nat Chem Biol
Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P.   +7 more
europepmc   +1 more source

Enzyme‐Substrate Complex Formation and Electron Transfer in Nitrogenase‐Like Dark‐Operative Protochlorophyllide Oxidoreductase (DPOR)

ChemistryOpen, EarlyView.
Dark‐operative protochlorophyllide oxidoreductase (DPOR) participates in photosynthesis by catalyzing the ATP‐dependent reduction of protochlorophyllide to chlorophyllide. Structurally and mechanistically resembling nitrogenase, DPOR′s mechanism was investigated using visible spectroscopy.
Giada Bedendi, Plinio Maroni, Ross D. Milton   +2 more
wiley   +1 more source

Allosteric regulation by c-di-AMP modulates a complete N-acetylglucosamine signaling cascade in Saccharopolyspora erythraea. [PDF]

Nat Commun
You D, Zhao LC, Fu Y, Peng ZY, Chen ZQ, Ye BC.   +5 more
europepmc   +1 more source

Arenaria serpyllifolia as a Natural Antiviolaceum Agent: Phytochemical, Biological, and Molecular Approaches

ChemistryOpen, EarlyView.
Arenaria serpyllifolia extract exhibits strong antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities. Key compounds, including levoglucosan and guanosine, show potent CviR receptor binding. Violacein inhibition and molecular dynamics confirm their stability, highlighting their potential as quorum sensing inhibitors and therapeutic ...
Meryem Burcu Külahcı, Betül Aydın, Emine Incilay Torunoğlu, Zekeriya Düzgün, Alper Durmaz, Erdi Can Aytar   +5 more
wiley   +1 more source

Exploring the Hemoglobin T to R2 Path Using Gaussian Elastic Network Correlation Map Distance

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are dynamic and undergo conformational changes. These changes may affect the motions executed by different regions of the proteins and are reflected in the motion correlation map. A method to accurately measure these changes is presented and exemplified on a set of tetrameric Hemoglobin structures.
Yuval Valenci, Dror Tobi
wiley   +1 more source

The SIRT1 N‐Terminal Domain as a Common Binding Interface for PPARγ Anchoring

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Insulin resistance, a global health threat linked to type 2 diabetes and obesity, can be addressed by modulating the activity of the Sirtuin 1 (SIRT1), a deacetylase that enhances insulin sensitivity by deacetylating the Peroxisome Proliferator‐Activated Receptor Gamma (PPARγ) at lysine 268 and 293. Understanding the binding interfaces between
Caique Camargo Malospirito, Gabriel Ernesto Jara, Víctor Ulian Antunes, Giovanna Blazutti Elias, Marieli Mariano Goncalves Dias, Fernanda Aparecida Heleno Batista, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira   +7 more
wiley   +1 more source

Mechanistic insights into allosteric regulation of the reductase component of p-hydroxyphenylacetate 3-hydroxylase by p-hydroxyphenylacetate: a model for effector-controlled activity of redox enzymes. [PDF]

RSC Chem Biol
Visitsatthawong S, Anuwan P, Lawan N, Chaiyen P, Wongnate T.   +4 more
europepmc   +1 more source

Responses to Ligand Binding in the Bacterial DNA Sliding Clamp “β‐Clamp” Manifest in Dynamic Allosteric Effects

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The homo‐dimeric, ring‐shaped bacterial DNA sliding clamp, β‐clamp, is a central hub in DNA replication and repair. It interacts with a plethora of proteins via their short linear motifs, binding to the same hydrophobic binding pocket on β‐clamp. Although the structure, functions, and interactions of β‐clamp have been amply studied, less focus
Signe Simonsen, Andreas Prestel, Eva C. Østerlund, Marit Otterlei, Thomas J. D. Jørgensen, Birthe B. Kragelund   +5 more
wiley   +1 more source