Results 201 to 210 of about 127,473 (347)

Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: Implications for allosteric regulation

, 2000
James A. Endrizzi, Peter T. Beernink, Tom Alber, H. K. Schachman   +3 more
openalex   +1 more source

ADPglucose pyrophosphorylase’s N-terminus: Structural role in allosteric regulation [PDF]

, 2006
Clarisa Maria Bejar, Miguel A. Ballícora, Alberto Á. Iglesias, J. Preiss   +3 more
openalex   +1 more source

Disease‐Modifying Trials in Treated Parkinson's Disease: “Stable Treated” Does Not Equate with Biological Stability

Movement Disorders, EarlyView.
Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
M. Maral Mouradian, A. Jon Stoessl, Anthony E. Lang   +2 more
wiley   +1 more source

Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2. [PDF]

Nat Commun
Kugawa M, Kawakami K, Kise R, Suomivuori CM, Tsujimura M, Kobayashi K, Kojima A, Inoue WJ, Fukuda M, Matsui TE, Fukunaga A, Koyanagi J, Kim S, Ikeda H, Yamashita K, Saito K, Ishikita H, Dror RO, Inoue A, Kato HE.   +19 more
europepmc   +1 more source

Loss of allosteric regulation in α-isopropylmalate synthase identified as an antimicrobial resistance mechanism. [PDF]

NPJ Antimicrob Resist, 2023
Sullivan JR, Courtine C, Taylor L, Solomon O, Behr MA.   +4 more
europepmc   +1 more source

Proteolytic Fragments of Insulysin (IDE) Retain Substrate Binding but Lose Allosteric Regulation [PDF]

, 2006
Eun Suk Song, Clint Cady, Michael G. Fried, Louis B. Hersh   +3 more
openalex   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Structure, Function, and Allosteric Regulation of the 20S Proteasome by the 11S/PA28 Family of Proteasome Activators. [PDF]

Biomolecules, 2023
Thomas T, Salcedo-Tacuma D, Smith DM.
europepmc   +1 more source

Structural Basis for Allosteric Substrate Specificity Regulation in Anaerobic Ribonucleotide Reductases

, 2001
Karl-Magnus Larsson, Jessica Andersson, Britt‐Marie Sjöberg, P. Nordlund, Derek T. Logan   +4 more
openalex   +1 more source

A Pathogenic Linked Mutation in the Catalytic Core of Human Cystathionine β-Synthase Disrupts Allosteric Regulation and Allows Kinetic Characterization of a Full-Length Dimer [PDF]

, 2007
Suvajit Sen, Ruma Banerjee
openalex   +1 more source