Results 201 to 210 of about 130,472 (328)

eLife Assessment: Domain coupling in allosteric regulation of SthK measured using time-resolved transition metal ion FRET

León D Islas
openalex   +1 more source

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas, E. Flores‐Hernández, C. Cardona‐Félix, E. Rudiño‐Piñera   +3 more
wiley   +1 more source

The Allosteric Regulation of the DNA-Binding Domain of p53 by the Intrinsically Disordered C-Terminal Domain. [PDF]

Pharmaceuticals (Basel)
Ning S, Zeng C, Wang H, Zhang J, Xue Y, Zhao Y.   +5 more
europepmc   +1 more source

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source

A dynamic structural framework for the allosteric regulation of Hsp70 chaperones. [PDF]

J Biol Chem
Rohland L, Kityk R, Smalinskaitė-Wolf L, Lashkul V, Mayer MP.   +4 more
europepmc   +1 more source

Emerging maps of allosteric regulation in cellular networks. [PDF]

Curr Opin Struct Biol, 2023
Mathy CJP, Kortemme T.
europepmc   +1 more source

Allosteric regulation of the partitioning of glucose-1-phosphate between glycogen and trehalose biosynthesis in Mycobacterium tuberculosis

, 2014
Matías D. Asención Diez, Ana M. Demonte, Karl Syson, Diego G. Arias, Andrii Gorelik, Sergio A. Guerrero, Stephen Bornemann, Alberto Á. Iglesias   +7 more
openalex   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Regulation of Insulin Secretion Through Long‐Chain Fatty Acid Receptors

iNew Medicine, EarlyView.
Stefan Offermanns
wiley   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, EarlyView.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source