Results 211 to 220 of about 127,473 (347)

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

Intradomain Allosteric Regulation of Soluble Epoxide Hydrolase by Its Substrates. [PDF]

Int J Mol Sci
Matsumura S, Shida A, Tsuchii M, Wada M, Charneau J, Tsuji M, Hasumi K, Suzuki E.   +7 more
europepmc   +1 more source

Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family. [PDF]

Nat Commun, 2023
Deshmukh FK, Ben-Nissan G, Olshina MA, Füzesi-Levi MG, Polkinghorn C, Arkind G, Leushkin Y, Fainer I, Fleishman SJ, Tawfik D, Sharon M.   +10 more
europepmc   +1 more source

Identification of Regions Critically Affecting Kinetics and Allosteric Regulation of theEscherichia coliADP-Glucose Pyrophosphorylase by Modeling and Pentapeptide-Scanning Mutagenesis [PDF]

, 2007
Miguel A. Ballícora, Esteban Erben, Terutaka Yazaki, Ana L. Ferreira Bertolo, Ana M. Demonte, Jennifer R. Schmidt, Mabel Aleanzi, Clarisa Maria Bejar, Carlos M. Figueroa, Corina M. Fusari, Alberto Á. Iglesias, Jack Preiss   +11 more
openalex   +1 more source

Progress in Molecular Imprinting—From Inhibition of Enzymatic Activity to Regulation of Cellular Pathways

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular imprinting is a very powerful tool in life science. The research areas benefiting from a wide range of capabilities of molecularly imprinted polymeric nanoparticles (nanoMIPs) include sample preparation, extraction, sensing/detection, diagnostics, and drug delivery.
Milada Vodova, Jaroslava Bezdekova, Marketa Vaculovicova   +2 more
wiley   +1 more source

Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. [PDF]

J Biol Chem, 2023
O'Neill AG, Burrell AL, Zech M, Elpeleg O, Harel T, Edvardson S, Mor-Shaked H, Rippert AL, Nomakuchi T, Izumi K, Kollman JM.   +10 more
europepmc   +1 more source

Structural Analysis of the Bacterial HPr Kinase/Phosphorylase V267F Mutant Gives Insights into the Allosteric Regulation Mechanism of This Bifunctional Enzyme [PDF]

, 2007
Vincent Chaptal, Fanny Vincent, Virginie Gueguen‐Chaignon, Vicente Monedero, Sandrine Poncet, Josef Deutscher, Sylvie Nessler, S. Moréra   +7 more
openalex   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Conformational Remodeling and Allosteric Regulation Underlying EGFR Mutant-Induced Activation: A Multi-Scale Analysis Using MD, MSMs, and NRI. [PDF]

Int J Mol Sci
Duan H, Zhao DR, Liu MT, Yang LQ, Sang P.   +4 more
europepmc   +1 more source

Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. [PDF]

Protein Cell, 2023
Liu L, Wang P, Liu A, Zhang L, Yan L, Guo Y, Xiao G, Rao Z, Lou Z.   +8 more
europepmc   +1 more source