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Allosteric regulation of chaperonins
Current Opinion in Structural Biology, 2005Chaperonins are molecular machines that facilitate protein folding by undergoing energy (ATP)-dependent movements that are coordinated in time and space by complex allosteric regulation. Recently, progress has been made in describing the various functional (allosteric) states of these machines, the pathways by which they interconvert, and the coupling ...
Horovitz, A, Willison, KR
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Diversity of Allosteric Regulation in Proteases
ACS Chemical Biology, 2012Allostery is a fundamental regulatory mechanism that is based on a functional modulation of a site by a distant site. Allosteric regulation can be triggered by binding of diverse allosteric effectors, ranging from small molecules to macromolecules, and is therefore offering promising opportunities for functional modulation in a wide range of ...
Merdanovic, Melisa +3 more
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NADPH Is an Allosteric Regulator of HSCARG
Journal of Molecular Biology, 2009NADP(H) is an important cofactor that controls many fundamental cellular processes. We have determined the crystal structure of HSCARG, a novel NADPH sensor, and found that it forms an asymmetrical dimer with only one subunit occupied by an NADPH molecule, and the two subunits have dramatically different conformations.
Geng Meng +8 more
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Allosteric regulation of phosphoribulokinase activity
Biochemical and Biophysical Research Communications, 1968Inhibition of ATP-dependent CO2 fixation by AMP has been reported in several autotrophic organisms (Johnson and Peck, 1965; Mayeux and Johnson, 1966;Johnson, 1966; Gale and Beck, 1966). Johnson (1966) suggested that the site of AMP inhibition is phosphoribulokinase and that inhibition may occur through allosteric modification of the enzyme. In contrast,
Emmett J. Johnson +2 more
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The role of dynamics in allosteric regulation
Current Opinion in Structural Biology, 2003The biomolecular conformational changes often associated with allostery are, by definition, dynamic processes. Recent publications have disclosed the role of pre-existing equilibria of conformational substates in this process. In addition, the role of dynamics as an entropic carrier of free energy of allostery has been investigated.
Erik R. P. Zuiderweg, Dorothee Kern
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Allosteric regulation of crocodilian haemoglobin
Nature, 1981The oxygen affinity of most vertebrate haemoglobins in the absence of diffusible electrolytes is much higher than that of blood. In the red cell this affinity is lowered by organic phosphates, hydrogen ions, chloride ions and CO2 (refs 1–5). Similarly, crocodilian haemoglobin also has a much higher oxygen affinity than crocodile blood, but this is due ...
Perutz, Max M.F. +8 more
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Allosteric regulation of platelet actomyosin
Biochemical and Biophysical Research Communications, 1973Abstract The kinetic properties of platelet actomyosin have been examined to understand the mode of hydrolysis of its substrate ATP. In the presence of divalent cations, ATP hydrolysis deviated from Michaelis-Menten kinetics in such a way as to indicate cooperative effects, with a sigmoidal velocity vs.
Thomas C. Detwiler +2 more
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DNA as an Allosteric Regulator
Science Signaling, 2009The sequence of the DNA binding site affects the transcriptional regulatory activity of the glucocorticoid receptor.
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Allosteric regulation of Warts
Science Signaling, 2016Hippo pathway regulators allosterically switch the conformation of the kinase Warts.
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Allosteric Regulation of Chromatin-Modifying Enzymes
Biochemistry, 2018Dynamic changes in chromatin structure are crucial for diverse biological processes. Given the complexity of the epigenetic landscape, understanding the specificity of chromatin modification has been a major interest in the epigenetics field. Recent progress in biochemical and structural analyses in the field of chromatin biology has revealed that ...
Jung-Ae Kim, Minjung Kwon, Jaehoon Kim
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