Results 231 to 240 of about 127,473 (347)

Allosteric regulation in drug design [PDF]

Current Trends in Biomedical Engineering & Biosciences, 2017
openaire   +2 more sources

Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights

ChemistryOpen, EarlyView.
The study investigates the sedative potential of naringenin (NAR) through in vivo and in silico approaches. NAR significantly enhances sleep duration and reduces latency in mice, especially when combined with diazepam. Molecular docking shows strong binding to GABAA receptors, suggesting a GABAergic mechanism.
Dipu Bishwas, Md. Shimul Bhuia, Salehin Sheikh, Mohammed Alfaifi, Abdul Malik, Nikhat J. Siddiqui, Divya Jain, Mehedi Hasan Bappi, Muhammad Torequl Islam   +8 more
wiley   +1 more source

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow. [PDF]

mSystems
She F, Anderson BW, Khana DB, Zhang S, Steinchen W, Fung DK, Lesser NG, Lucas LN, Stevenson DM, Astmann TJ, Bange G, van Pijkeren J-P, Amador-Noguez D, Wang JD.   +13 more
europepmc   +1 more source

Mutational Insight into Allosteric Regulation of Kir Channel Activity. [PDF]

ACS Omega, 2022
Yekefallah M, Rasberry CA, van Aalst EJ, Browning HP, Amani R, Versteeg DB, Wylie BJ.   +6 more
europepmc   +1 more source

Kinetic Evidence for Interdomain Communication in the Allosteric Regulation of α-Isopropylmalate Synthase from Mycobacterium tuberculosis [PDF]

, 2009
Luiz Pedro S. de Carvalho, Patrick A. Frantom, Argyrides Argyrou, John S. Blanchard   +3 more
openalex   +1 more source

Enzyme‐Substrate Complex Formation and Electron Transfer in Nitrogenase‐Like Dark‐Operative Protochlorophyllide Oxidoreductase (DPOR)

ChemistryOpen, EarlyView.
Dark‐operative protochlorophyllide oxidoreductase (DPOR) participates in photosynthesis by catalyzing the ATP‐dependent reduction of protochlorophyllide to chlorophyllide. Structurally and mechanistically resembling nitrogenase, DPOR′s mechanism was investigated using visible spectroscopy.
Giada Bedendi, Plinio Maroni, Ross D. Milton   +2 more
wiley   +1 more source

Structural basis of frizzled 7 activation and allosteric regulation. [PDF]

Nat Commun
Bous J, Kinsolving J, Grätz L, Scharf MM, Voss JH, Selcuk B, Adebali O, Schulte G.   +7 more
europepmc   +1 more source

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes. [PDF]

Elife, 2023
Touray AO, Rajesh R, Isebe T, Sternlieb T, Loock M, Kutova O, Cestari I.   +6 more
europepmc   +1 more source

Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 1. Calorimetric Study [PDF]

, 2009
Petr Heřman, J. Ching Lee
openalex   +1 more source

Arenaria serpyllifolia as a Natural Antiviolaceum Agent: Phytochemical, Biological, and Molecular Approaches

ChemistryOpen, EarlyView.
Arenaria serpyllifolia extract exhibits strong antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities. Key compounds, including levoglucosan and guanosine, show potent CviR receptor binding. Violacein inhibition and molecular dynamics confirm their stability, highlighting their potential as quorum sensing inhibitors and therapeutic ...
Meryem Burcu Külahcı, Betül Aydın, Emine Incilay Torunoğlu, Zekeriya Düzgün, Alper Durmaz, Erdi Can Aytar   +5 more
wiley   +1 more source