Results 231 to 240 of about 63,430 (242)
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Nucleosomes as allosteric scaffolds for genetic regulation
Current Opinion in Structural Biology, 2020Nucleosomes are stable yet highly dynamic complexes exhibiting diverse types of motions, such as sliding, DNA unwrapping, and disassembly, encoding a landscape with a large number of metastable states. In this review, describing recent studies on these nucleosome structure changes, we propose that the nucleosome can be viewed as an ideal allosteric ...
Shoji Takada +2 more
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The ribosome as an allosterically regulated molecular machine
Biochemistry (Moscow), 2017The ribosome as a complex molecular machine undergoes significant conformational rearrangements during the synthesis of polypeptide chains of proteins. In this review, information obtained using various experimental methods on the internal consistency of such rearrangements is discussed.
T. M. Makarova, Alexey A. Bogdanov
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Design of Allosterically Regulated Protein Catalysts
Biochemistry, 2015Activity of allosteric protein catalysts is regulated by an external stimulus, such as protein or small molecule binding, light activation, pH change, etc., at a location away from the active site of the enzyme. Since its original introduction in 1961, the concept of allosteric regulation has undergone substantial expansion, and many, if not most ...
Elizabeth A. Raymond +2 more
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Allosteric regulation of purine nucleoside phosphorylase
Archives of Biochemistry and Biophysics, 1991Purine nucleoside phosphorylase (EC 2.4.2.1) from bovine spleen is allosterically regulated. With the substrate inosine the enzyme displayed complex kinetics: positive cooperativity vs inosine when this substrate was close to physiological concentrations, negative cooperativity at inosine concentrations greater than 60 microM, and substrate inhibition ...
Patricia A. Ropp, Thomas W. Traut
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Mechanism of Allosteric Regulation of Dnmt1's Processivity
Biochemistry, 2005We have analyzed the relationship between the allosteric regulation and processive catalysis of DNA methyltransferase 1 (Dnmt1). Processivity is described quantitatively in terms of turnover rate, DNA dissociation rate, and processivity probability. Our results provide further evidence that the active site and the allosteric sites on Dnmt1 can bind DNA
Norbert O. Reich +1 more
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Allosteric regulation, cooperativity, and biochemical oscillations
Biophysical Chemistry, 1990Allosteric regulation is associated with a number of periodic phenomena in biochemical systems. The cooperative nature of such regulatory interactions provides a source of nonlinearity that favors oscillatory behavior. We assess the role of cooperativity in the onset of biochemical oscillations by analyzing two specific examples.
Goldbeter, Albert, Dupont, Geneviève
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An engineered chorismate mutase with allosteric regulation
Bioorganic & Medicinal Chemistry, 2003Besides playing a central role in phenylalanine biosynthesis, the bifunctional P-protein in Eschericia coli provides a unique model system for investigating whether allosteric effects can be engineered into protein catalysts using modular regulatory elements.
Sheng Zhang, Bruce Ganem, David Wilson
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An Allosterically Regulated Molecular Shuttle
Angewandte Chemie International Edition, 2006Dana S. Marlin +3 more
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Ribonucleotide Reductases: The Evolution of Allosteric Regulation
Archives of Biochemistry and Biophysics, 2002Ribonucleotide reductases catalyze in all living organisms the production of the deoxyribonucleotides required for DNA replication and repair. Their appearance during evolution was a prerequisite for the transition from the "RNA world," where RNA sufficed for both catalysis and information transfer, to today's situation where life depends on the ...
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An Allosteric Ribozyme Regulated by Doxycyline
Angewandte Chemie, 2000Vincent Thuillier +3 more
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