Results 251 to 260 of about 127,473 (347)

Allosteric regulation of protease activity by small molecules [PDF]

, 2010
Aimee Shen
openalex   +1 more source

The SIRT1 N‐Terminal Domain as a Common Binding Interface for PPARγ Anchoring

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Insulin resistance, a global health threat linked to type 2 diabetes and obesity, can be addressed by modulating the activity of the Sirtuin 1 (SIRT1), a deacetylase that enhances insulin sensitivity by deacetylating the Peroxisome Proliferator‐Activated Receptor Gamma (PPARγ) at lysine 268 and 293. Understanding the binding interfaces between
Caique Camargo Malospirito, Gabriel Ernesto Jara, Víctor Ulian Antunes, Giovanna Blazutti Elias, Marieli Mariano Goncalves Dias, Fernanda Aparecida Heleno Batista, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira   +7 more
wiley   +1 more source

The mechanism of allosteric regulation of calcium-independent phospholipase A₂ by ATP and calmodulin binding to the ankyrin domain. [PDF]

Proc Natl Acad Sci U S A
Mouchlis VD, Hsu YH, Hayashi D, Cao J, Li S, McCammon JA, Dennis EA.   +6 more
europepmc   +1 more source

The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases. [PDF]

Protein Sci, 2022
Buey RM, Fernández-Justel D, Jiménez A, Revuelta JL.   +3 more
europepmc   +1 more source

Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue

, 2006
Fiona E. Baird, Jorge J. Pinilla-Tenas, William L. J. Ogilvie, Vadival Ganapathy, Harinder S. Hundal, Peter M. Taylor   +5 more
openalex   +2 more sources

Engineering allosteric regulation into the hinge region of a circularly permuted TEM-1 β-lactamase [PDF]

, 2010
Valéry Mathieu, Jacques Fastrez, Patrice Soumillion   +2 more
openalex   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Proteolytic stabilization of a spider venom peptide results in an orally active bioinsecticide

Pest Management Science, EarlyView.
Selective editing out of an insect gut protease cleavage site renders a spider‐derived insecticidal peptide active by ingestion by insect pests. Abstract BACKGROUND The toxin peptide U1‐AGTX‐Ta1b from the Hobo spider, Eratigena agrestis (Walckenaer, 1802), was studied to determine its potential to serve as a bioinsecticide.
Breck R. Davis, Alexandra M. Haase, Joseph S. Tourtois, Daniel L. Hulbert, Rachel E. Cornell, Brian T. DeVree, Cadence J. Flohrschutz, Lucille M. Bell, Daniel C. Peck, Trang T. Nguyen, Lin Bao, Robert M. Kennedy, Kyle D. Schneider   +12 more
wiley   +1 more source

Quantifying Dynamic Regulation in Metabolic Pathways with Nonparametric Flux Inference [PDF]

, 2019
He, Fei, Stumpf, Michael P H
core   +1 more source

Co(II)-substituted Haemophilus influenzae β-carbonic anhydrase: Spectral evidence for allosteric regulation by pH and bicarbonate ion [PDF]

, 2011
Katherine Hoffmann, Dejan Samardzic, Katherine van den Heever, Roger S. Rowlett   +3 more
openalex   +1 more source