Results 61 to 70 of about 19,917 (239)

Engineering Novel DNA Nanoarchitectures for Targeted Drug Delivery and Aptamer Mediated Apoptosis in Cancer Therapeutics

Advanced Functional Materials, EarlyView.
Designer DNA Architecture‐templated Drug Conjugates (DDA‐DCs) are comprised of a DNA nanomaterial decorated with multiple drug‐loaded DNA aptamers. DDA‐DCs use a combination of multiple aptamer types, each recognizing a different membrane protein to achieve precise targeting of cancer cells.
Abhisek Dwivedy, Dhyanesh Baskaran, Gaurav Sharma, Wei Hong, Dhanush Gandavadi, Abhichart Krissanaprasit, Joonsu Han, Yusheng Liu, Zack Zimmers, Tshepo Mafokwane, Ichrak Hayah, Neha Chauhan, Mengxi Zheng, Sherwood Yao, Keith Fraser, John S. Decker, Xiaohe Jin, Hua Wang, Adam D. Friedman, Xing Wang   +19 more
wiley   +1 more source

Atropisomerism in Triarylboranes: Lewis Base Assisted Rotation at C−B Stereogenic Axis in Asymmetrical Boron Lewis Acids

Angewandte Chemie, EarlyView.
From decades to minutes: regulation of the rotation speed at the C−B chirality axis by peri‐substituents and Lewis acid‐base interactions in unprecedented triarylboranes with a C−B stereogenic axis enabled to reach atropostable and enantiopure triarylboranes.
Thu‐Hong Doan, Aurélien Chardon, Nicolas Vanthuyne, Tárcius N. Ramos, Nikolay Tumanov, Luca Fusaro, Muriel Albalat, Laurent Collard, Johan Wouters, Benoît Champagne, Guillaume Berionni   +10 more
wiley   +2 more sources

Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine

Nature Communications, 2019
Large protein machines are tightly regulated through allosteric communication channels. Here authors use single-molecule FRET and demonstrate the involvement of ultrafast conformational dynamics in the allosteric regulation of ClpB, a hexameric AAA ...
Hisham Mazal, Marija Iljina, Yoav Barak, Nadav Elad, Rina Rosenzweig, Pierre Goloubinoff, Inbal Riven, Gilad Haran   +7 more
doaj   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Transition in relaxation paths in allosteric molecules: enzymatic kinetically constrained model [PDF]

Phys. Rev. Research 2, 012005 (2020), 2018
A hierarchy of timescales is ubiquitous in biological systems, where enzymatic reactions play an important role because they can hasten the relaxation to equilibrium. We introduced a statistical physics model of interacting spins that also incorporates enzymatic reactions to extend the classic model for allosteric regulation.
arxiv   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

In Situ Light‐driven pH Modulation for NMR Studies

Angewandte Chemie, EarlyView.
In this work, we introduce a novel approach to control pH in NMR samples using light‐activated photoacids. By combining light stimuli with pH‐sensitive molecules, we demonstrate the ability to precisely modulate pH without physically manipulating the sample.
Aarav Barde, Ruixian Han, Martin A. Olson, Marco Tonelli, Chad M. Rienstra, Katherine A. Henzler‐Wildman, Thirupathi Ravula   +6 more
wiley   +2 more sources

Molecular Synchronization Waves in Arrays of Allosterically Regulated Enzymes [PDF]

Phys. Rev. Lett. 99, 048301 (2007), 2007
Spatiotemporal pattern formation in a product-activated enzymic reaction at high enzyme concentrations is investigated. Stochastic simulations show that catalytic turnover cycles of individual enzymes can become coherent and that complex wave patterns of molecular synchronization can develop. The analysis based on the mean-field approximation indicates
arxiv   +1 more source

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

Advanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang, Yi Xie, Shenglong Xia, Xinnuo Ge, Jiaying Li, Fang Liu, Fan Jia, Shengyao Wang, Qiao Zhou, Menghan Gao, Weihuan Fang, Chao Zheng   +11 more
wiley   +1 more source

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
wiley   +1 more source