Results 61 to 70 of about 127,473 (347)

FimH as a scaffold for regulated molecular recognition

Journal of Biological Engineering, 2021
Background Recognition proteins are critical in many biotechnology applications and would be even more useful if their binding could be regulated. The current gold standard for recognition molecules, antibodies, lacks convenient regulation.
Shivani Gupta Ludwig, Casey L. Kiyohara, Laura A. Carlucci, Dagmara Kisiela, Evgeni V. Sokurenko, Wendy Evelyn Thomas   +5 more
doaj   +1 more source

The pharmacology and function of receptors for short-chain fatty acids [PDF]

, 2015
Despite some blockbuster G protein–coupled receptor (GPCR) drugs, only a small fraction (∼15%) of the more than 390 nonodorant GPCRs have been successfully targeted by the pharmaceutical industry.
Bolognini, Daniele, Milligan, Graeme, Moss, Catherine E., Tobin, Andrew B.   +3 more
core   +1 more source

Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR

Nature Communications
Allosteric drugs offer a new avenue for modern drug design. However, the identification of cryptic allosteric sites presents a formidable challenge. Following the allostery nature of residue-driven conformation transition, we propose a state-of-the-art ...
Xin Chen, Kexin Wang, Jianfang Chen, Chao Wu, Jun Mao, Yuanpeng Song, Yijing Liu, Zhenhua Shao, Xuemei Pu   +8 more
doaj   +1 more source

G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors [PDF]

, 2012
Work published over the past 10–15 years has caused the neuroscience community to engage in a process of constant re-evaluation of the roles of glial cells in the mammalian central nervous system.
Bradley, Sophie J., Challiss, R.A. John
core   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Known allosteric proteins have central roles in genetic disease.

PLoS Computational Biology, 2022
Allostery is a form of protein regulation, where ligands that bind sites located apart from the active site can modify the activity of the protein. The molecular mechanisms of allostery have been extensively studied, because allosteric sites are less ...
György Abrusán, David B Ascher, Michael Inouye   +2 more
doaj   +1 more source

Allosteric regulation of substrate channeling: Salmonella typhimurium tryptophan synthase

Frontiers in Molecular Biosciences, 2022
The regulation of the synthesis of L-tryptophan (L-Trp) in enteric bacteria begins at the level of gene expression where the cellular concentration of L-Trp tightly controls expression of the five enzymes of the Trp operon responsible for the synthesis ...
Rittik K. Ghosh, Eduardo Hilario, Chia-en A. Chang, Leonard J. Mueller, Michael F. Dunn   +4 more
doaj   +1 more source

Allosteric Modulators of Steroid Hormone Receptors : Structural Dynamics and Gene Regulation [PDF]

, 2012
Peer reviewedPublisher ...
Acevedo, Almlöf, Almlöf, Almlöf, Andersen, Babu, Bain, Ball, Barkhem, Baskakov, Beck, Benecke, Berry, Betney, Bevan, Bhasin, Billon-Galés, Bledsoe, Blind, Bolton, Boonyaratanakornkit, Briet, Brodie, Brzozowski, Bulynko, Börjesson, Callewaert, Carlstedt-Duke, Carlstedt-Duke, Carroll, Carroll, Centenera, Chamberlain, Chandra, Chang, Chen, Chen, Chen, Claessens, Conneely, Connell, Cutress, Cutress, Dahlman-Wright, Dahlman-Wright, Dahlman-Wright, Daniel, Darimont, Davies, Demarest, Doesburg, Dong, Dubbink, Duma, Dunker, Dunker, Dunker, Dyson, Dziedzic-Letka, Egea, Eick, Eisenhaber, Escriva, Estébanez-Perpiñá, Evans, Faus, Fawell, Ferreira, Fischer, Freeman, Fu, Fu, Fu, Funder, Fuse, Garza, Garza, Gaughan, Gellersen, Georgiakaki, Glass, Govindan, Green, Green, Green, Greene, Groeneweg, Gronemeyer, He, He, He, He, Heery, Hermann, Hill, Hilser, Hollenberg, Hollenberg, Holthauzen, Huang, Hur, Härd, Iain J. McEwan, Iakoucheva, Iakoucheva, Iñiguez-Lluhí, Jeltsch, Jenster, Joerger, Jones, Kaul, Khan, Khan, Kininis, Kjaergaard, Ko, Konduri, Kornberg, Krasowski, Kraus, Kulkarni, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Langley, Langley, Lanz, Lavery, Lavery, Lavery, Lefstin, Linding, Liu, Loven, Lubahn, Malik, Mao, Mao, Massie, McDonnell, McDonnell, McEwan, McEwan, McEwan, McEwan, McEwan, McEwen, McInerney, McKenna, McNally, Meijsing, Metzger, Midic, Miller, Mérot, Métivier, Nagaich, Nagy, Nettles, Nilsson, Nocula-£ugowska, Oakley, Oldfield, Onate, Paige, Picard, Pike, Pippal, Powell, Pratt, Prilusky, Putcha, Raj Kumar, Rajagopalan, Rayasam, Reid, Reid, Ricketson, Rochel, Roeder, Roemer, Rogatsky, Rogatsky, Rosenfeld, Savory, Schoenmakers, Schwabe, Schwabe, Shaffer, Shatkina, Shen, Shoemaker, Simental, Smith, Smith, So, So, Spillman, Stanisiæ, Stenoien, Street, Sugase, Surjit, Takimoto, Tanner, Tetel, Timasheff, Tompa, Tora, Tremblay, Tzukerman, Umetani, Uversky, Uversky, Vacic, van Royen, Verkhivker, Vicent, Wang, Wang, Wang, Wang, Wardell, Wardell, Wardell, Weigel, Weinberger, Wijayaratne, Wood, Wood, Wrange, Wright, Wärnmark, Xu, Yang, Yang, Yang, Yoon, Zennaro, Zhang, Zhao, Zilliacus, Zor   +251 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine

Nature Communications, 2019
Large protein machines are tightly regulated through allosteric communication channels. Here authors use single-molecule FRET and demonstrate the involvement of ultrafast conformational dynamics in the allosteric regulation of ClpB, a hexameric AAA ...
Hisham Mazal, Marija Iljina, Yoav Barak, Nadav Elad, Rina Rosenzweig, Pierre Goloubinoff, Inbal Riven, Gilad Haran   +7 more
doaj   +1 more source