Results 101 to 110 of about 18,737 (212)
PLoS Computational Biology, 2016 Allostery is one of the pervasive mechanisms through which proteins in living systems carry out enzymatic activity, cell signaling, and metabolism control.
Enrico Guarnera, Igor N Berezovsky
doaj +1 more source
Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation
eLife, 2020 Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the immune response. IMPDH reversibly polymerizes in cells and tissues in response to
Matthew C Johnson, Justin M Kollman
doaj +1 more source
Chemistry–Methods, Volume 6, Issue 2, February 2026.This review summarizes the unique benefits 19F NMR spectroscopy has to offer for the study of biological systems. Particular focus is laid on the available strategies for incorporation of fluorinated probes into proteins and the latest applications of the ever‐expanding toolbox of fluorine NMR methodology to study structure and dynamics.
Charles Burridge, Björn M. Burmann
wiley +1 more source
Engineering Allostery into Proteins
, 2019 Our ability to engineer protein structure and function has grown dramatically over recent years. Perhaps the next level in protein design is to develop proteins whose function can be regulated in response to various stimuli, including ligand binding, pH changes, and light.
Scott D, Gorman +3 more
openaire +3 more sources
A complex network perspective on brain disease
Biological Reviews, Volume 101, Issue 1, Page 364-399, February 2026.ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley +1 more source
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Nature Communications, 2016 Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven
Peter J. Watson +9 more
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Principles for optimal cooperativity in allosteric materials
, 2018 Allosteric proteins transmit a mechanical signal induced by binding a ligand. However, understanding the nature of the information transmitted and the architectures optimizing such transmission remains a challenge.
Brito, Carolina +3 more
core +1 more source
Allosteric cross-talk in chromatin can mediate drug-drug synergy
Nature Communications, 2017 Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin ...
Zenita Adhireksan +7 more
doaj +1 more source
New Peptide-Based Pharmacophore Activates 20S Proteasome
Molecules, 2020 The proteasome is a pivotal element of controlled proteolysis, responsible for the catabolic arm of proteostasis. By inducing apoptosis, small molecule inhibitors of proteasome peptidolytic activities are successfully utilized in treatment of blood ...
Paweł A. Osmulski +5 more
doaj +1 more source
Rigidity and flexibility of biological networks
, 2012 The network approach became a widely used tool to understand the behaviour of complex systems in the last decade. We start from a short description of structural rigidity theory.
Almaas +64 more
core +1 more source