Results 21 to 30 of about 42,423 (256)

Hypoglycemic, antidyslipidemic, and antioxidant activities of methanol extract of Struchium sparganophora leaves in alloxan-induced oxidative stress-mediated diabetes in rats

Future Journal of Pharmaceutical Sciences, 2020
Background Diabetes mellitus is clinically underlined by hyperglycemia and dyslipidemia. In view of this, the current study assessed the glycemic and lipidemic control potentials of methanol extract of Sruchium sparganophora leaves (SPA) in the alloxan ...
A. M. Adeosun, F. O. Asejeje, O. M. Ighodaro, B. A. Oluwole, O. A. Akinloye   +4 more
doaj   +1 more source

Antihyperglycemic effect and phytochemical investigation of Rubia cordifolia (Indian Madder) leaves extract

Open Chemistry, 2021
Medicinal plants are used as an important source of medicines in pharmaceutical industry. Rubia cordifolia is widely used to cure diabetes mellitus.
Khan Muhammad Shafiq, Aziz Shahid, Khan Muhammad Zakryya, Khalid Zafar Mahmood, Riaz Muhammad, Ahmed Dawood, Ali Iftikhar, Arif Nazia, Wang Deiji, Ahmad Muhammad Sheeraz, Zahid Nafeesa   +10 more
doaj   +1 more source

A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo [PDF]

, 2019
The pancreatic islet is a complex micro-organ containing numerous cell types, including endocrine, immune, and endothelial cells. The communication of these systems is lost upon isolation of the islets, and therefore the pathogenesis of diabetes can only
Conteh, Abass M., Day, Richard N., Dunn, Kenneth W., Kamocka, Malgorzata M., Linnemann, Amelia K., Martinez, Michelle M., Mirmira, Raghavendra G., Orr, Kara S., Piñeros, Annie R., Reissaus, Christopher A., Tersey, Sarah A., Twigg, Ashley N.   +11 more
core   +1 more source

Alloxan and Hypersensitivity [PDF]

Nature, 1961
DURING the course of another investigation, it was found that a diabetogenic dose of alloxan (175–200 mgm./kgm.)1 protects approximately 50 per cent of rats sensitized to horse serum and later injected intravenously with this antigen. The time of death was lengthened in those rats suffering lethal shock.
openaire   +2 more sources

Co-administration of caffeine and hydromethanolic fraction of Citrullus lanatus seeds improved testicular functions in alloxan-induced diabetic male Wistar rats

Asian Pacific Journal of Reproduction, 2016
Objective: To investigate the effect of Citrillus lanatus (C. lanatus) seeds and caffeine on blood glucose levels and testicular functions of alloxan-induced diabetic male Wistar rats. Methods: Alloxan was administered at a single dose of 150 mg/kg BW to
G.I. Onyeso, K.W. Nkpaa, S. Omenihu
doaj   +1 more source

Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice

Brazilian Journal of Biology, 2022
Plants have profound therapeutic benefits, more economical treatments, fewer side effects, and a relatively cheap cost, making them a source of drugs for protective, preventative, curative, or conducive purposes and creating novel phytomedicines.
S. Rahman, Gul Jan, F. Gul Jan, H. Ur Rahim   +3 more
doaj   +1 more source

Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior [PDF]

, 2017
Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V).
Barahona, María José, Elizondo Vega, Roberto, García Robles, María de los Ángeles, Martinez, Fernando, Millán, Carola, Ordenes, Patricio, Recabal, Antonia, Salgado, Magdiel, Sepúlveda, Fernando, Uranga, Romina Maria, Uribe, Elena   +10 more
core   +1 more source

Ameliorative Effects of Annona muricata Leaf Ethanol Extract on Renal Morphology of Alloxan-Induced Mice

Applied Sciences, 2022
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, which affects multiple tissues including kidneys. Soursop leaves (Annona muricata) are known to have antidiabetic potential, but their molecular and cellular effects ...
Supri Irianti Handayani, Mutiara Intan Permata Sari, Meilania Saraswati Sardjana, Kusmardi Kusmardi, Siti Nurbaya, Rosmalena Rosmalena, Ernawati Sinaga, Vivitri Dewi Prasasty   +7 more
doaj   +1 more source

Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: Medicinal plants provide better and cheaper alternative therapy for management of several diseases compared to orthodox medicines. This study evaluated the effects of feed formulated with Ficus ottoniifolia (Miq.) Miq.
Chinyere Aloke, Ngwu Nwachukwu, Nwogo Obasi, Chinedum Emelike, Pascal Amu, Patience Ogbu, Onyebuchi Orinya, Egwu Ogbonnia   +7 more
doaj   +1 more source

Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies

Medicina, 2017
Glycemic homeostasis refers to glucose balance or control within circulation in living organisms. It is normally and largely compromised in diabetes. The compromise when exacerbated, leads to several complications including retinopathy, nephropathy and ...
Osasenaga Macdonald Ighodaro, Abiola Mohammed Adeosun, Oluseyi Adeboye Akinloye   +2 more
doaj   +1 more source