Results 11 to 20 of about 10,812 (185)
Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches. [PDF]
Animal Model Exp MedThis review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Faraji M, Faraji M, Kazemipour N.
europepmc +2 more sources
Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological Insights [PDF]
Chem BiodiversPhytochemical and biological profiling of Launaea mucronata aerial parts reveals six bioactive constituents alongside potent antioxidant and antidiabetic properties. The hydroethanolic extract inhibits key carbohydrate‐metabolizing enzymes and exerts marked hypoglycemic and insulinotropic effects with histological restoration of metabolic organs in ...
Mohamed A +5 more
europepmc +2 more sources
Lipids in Health and Disease, 2012 Background Type 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by insulin resistance. Its development is directly connected with the inability of insulin to exert its action, not just on carbohydrate metabolism but also on ...
Ribeiro Carla +6 more
doaj +1 more source
Antioxidant effectsof Moringa oleiferaseed oil against oxidative stress induced by alloxan in rats.
International Journal of Endorsing Health Science Research, 2020 Background:Type I diabetes mellitusis a metabolic syndrome manifested with chronic hyperglycemia due to insufficient insulin secretion. Hyperglycemia in diabetes mellitushas been associated with the overproduction of reactive oxygen ...
Abeer Sajid +5 more
doaj +1 more source
Diabetology & Metabolic Syndrome, 2012 Background This study aimed to examine the effects of intermittent and continuous swimming training on muscle protein metabolism in neonatal alloxan-administered rats.
Ribeiro Carla +8 more
doaj +1 more source
Alloxan and Hypersensitivity [PDF]
Nature, 1961 DURING the course of another investigation, it was found that a diabetogenic dose of alloxan (175–200 mgm./kgm.)1 protects approximately 50 per cent of rats sensitized to horse serum and later injected intravenously with this antigen. The time of death was lengthened in those rats suffering lethal shock.
openaire +2 more sources
مجلة كلية الطب, 2010 Background:The diabetogenic agent alloxan is a selective necrosis of insulin producing cells .Alloxan accumulated rapidly in liver and pancreatic islets , this study was carried out to evaluate the antidiabetic effect of cinnamon oil on the destructive ...
Mahera N. AL – Shaikh
doaj +1 more source
Asian Pacific Journal of Reproduction, 2016 Objective: To investigate the effect of Citrillus lanatus (C. lanatus) seeds and caffeine on blood glucose levels and testicular functions of alloxan-induced diabetic male Wistar rats. Methods: Alloxan was administered at a single dose of 150 mg/kg BW to
G.I. Onyeso, K.W. Nkpaa, S. Omenihu
doaj +1 more source
Future Journal of Pharmaceutical Sciences, 2020 Background Diabetes mellitus is clinically underlined by hyperglycemia and dyslipidemia. In view of this, the current study assessed the glycemic and lipidemic control potentials of methanol extract of Sruchium sparganophora leaves (SPA) in the alloxan ...
A. M. Adeosun +4 more
doaj +1 more source
Open Chemistry, 2021 Medicinal plants are used as an important source of medicines in pharmaceutical industry. Rubia cordifolia is widely used to cure diabetes mellitus.
Khan Muhammad Shafiq +10 more
doaj +1 more source