Results 31 to 40 of about 10,812 (185)

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3973-3988, November 2026.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

MECHANISMS OF ACTION OF THE POWDER OF CURCUMA LONGA RHIZOME PLANT ON A CARBOHYDRATE METABOLISM AT ALLOXAN-INDUCED DIABETIC RATS

Бюллетень сибирской медицины, 2014
Aim. The effects of the powder of Curcuma longa plant rhizome as food additive on different processes of carbohydrate metabolism: glucose concentration in whole blood, concentration of hormones – insulin and C-peptide in plasma, content of glycogen in ...
R. I. Aizman, G. A. Koroschenko, A. P. Gaidarova, M. A. Subotyalov, S. N. Lukanina, A. V. Sakharov   +5 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, Volume 15, Issue 38, 16 October 2026.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Peculiarities of ionoregulatory renal function of rats in the dynamics of experimental diabetes mellitus development

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. The purpose of the research was to study the peculiarities of ionoregulatory renal function in the dynamics of alloxan-induced experimental diabetes mellitus. Materials and methods.
О.А. Olenovych
doaj   +1 more source

Ammodaucus leucotrichus Coss. & Durieu: Antihyperglycemic activity via the inhibition of α-amylase, α-glucosidase, and intestinal glucose absorption activities and its chemical composition. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: Ammodaucus leucotrichus commonly known as a ‘Kamune es sufi or akâman’ in Morocco, is used to treat many diseases including diabetes. Aims: To investigate the antihyperglycemic activity of an aqueous extract of fruits A.
Saliha Bouknana, Nour Elhouda Daoudi, Mohamed Bouhrim, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Hassane Mekhfi, Mohamed Bnouham   +6 more
doaj  

Harnessing Terminalia arjuna in Next Generation Phytomedicine: Cutting Edge Nutraceutical Trends Shaping Food and Health

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee, Fahika Nazeerulla, Manash Kumar Paul, Sujit Kumar Bhutia, Deblina Basu, Subhadip Mukhopadhyay   +5 more
wiley   +1 more source

ANTIDIABETIC ACTIVITY TEST USING AMLA FRUIT (PHYLLANTHUS EMBLICA L) EXTRACT IN ALLOXAN-INDUCED BALB/C MICE

Journal of Vocational Health Studies, 2019
Background: The content of secondary metabolites in amla (phyllanthus emblica L.) such as flavonoids and phenols have the potential as an antioxidant.
Putu Lakustini Cahyaningrum, Sang Ayu Made Yuliari, Ida Bagus Putra Suta   +2 more
doaj   +1 more source

The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male rats

Journal of Taibah University for Science, 2020
The leaf and twig aqueous extracts of Arabian balsam tree (Commiphora gileadensis) were tested to protect against alloxan-induced hyperglycaemia in hypercholesterolemic male rats.
Haddad A. El Rabey, Abdulbasit I. Al-Sieni, Madeha N. Al-Seeni, Mohammed A. Alsieni, Adel I. Alalawy, Fahad M. Almutairi   +5 more
doaj   +1 more source

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

Artikel Review: Pengaruh Pemberian Induksi Aloksan Terhadap Gula Darah Tikus

Indonesian Journal of Pharmaceutical Education
Diabetes mellitus is known as a condition where metabolic disorders occur accompanied by increased blood sugar levels in the body. Antidiabetic agent testing was developed using experimental animals and involves chemical components that have diabetogenic
Ni Luh Wayan Eva Wulandari, Ni Nyoman Wahyu Udayani, Ni Luh Kade Arman Anita Dewi, Ginza Afriyanchika Putri Triansyah, Ni Putu Eka Mahita Kumari Dewi, Ida Ayu Putu Widiasriani, Anak Agung Sagung Sri Prabandari   +6 more
doaj   +1 more source