Results 21 to 30 of about 3,282 (84)

Alkinyltriazene in photochemischen metallfreien Doyle‐Kirmse‐Umlagerungen

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
Es wird eine metall‐ und additivfreie photokatalytische Doyle‐Kirmse‐Reaktion von Alkinyltriazenen beschrieben, die über Cyancarbenzwischenstufen verläuft. Diese Strategie ermöglicht den effizienten Aufbau hochsubstituierter asymmetrischer Kohlenstoffzentren mit breitem Substratspektrum und liefert synthetisch wertvolle Nitrile.
Ningning Liu, Linus Bjarne Dittmer, Melina Maag, Elena Michel, Frank Rominger, Matthias Rudolph, Andreas Dreuw, A. Stephen K. Hashmi   +7 more
wiley   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, Volume 36, Issue 16, 23 February 2026.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Beyond Traditional RAFT Polymerization: Emerging Strategies and Future Perspectives; A Third Update

Advanced Science, Volume 13, Issue 12, 27 February 2026.
This review explores recent advances in the past five years for non‐traditional RAFT polymerization, focusing on new activation strategies, sustainable depolymerization, and integration with automated and AI‐driven synthesis. Together, these innovations advance polymer chemistry and reveal how the pieces of the non‐traditional RAFT puzzle are steadily ...
Vianna F. Jafari, James L. Grace, Jiajia Li, Joji Tanaka, Glen R. Jones, Athina Anastasaki, Wei You, Jian Zhu, Masami Kamigaito, Cyrille Boyer, Greg G. Qiao   +10 more
wiley   +1 more source

Harmine Derivatives as Anticancer Agents Endowed With Potent and Selective Antileukemia Activity: Synthesis, Biological Evaluation, Proapoptotic and Genotoxic Activity

Archiv der Pharmazie, Volume 359, Issue 2, February 2026.
We identified a novel N9‐substituted harmine analog, compound 6, that selectively suppresses leukemic cell growth, triggers DNA damage, and activates apoptosis while sparing healthy fibroblasts. This discovery highlights N9‐modified β‐carbolines as a powerful new class of selective antileukemic agents, bridging natural product chemistry with next ...
Abdul Aziz Timbilla, Filip Pidany, Eliska Kohelova, Jana Kroustkova, Karel Kralovec, Jan Rataj, Martina Ceckova, Negar Maafi, Víctor Lopez, Cristina Moliner Langa, Stefan Kosturko, Jaroslav Jenco, Darina Muthna, Darja Koutova, Martina Rezacova, Lucie Cahlikova, Jakub Chlebek, Radim Havelek   +17 more
wiley   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase

Plant Biotechnology Journal, Volume 24, Issue 2, Page 567-581, February 2026.
ABSTRACT Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched‐chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron–sulfur clusters and hydrophobic interactions with Tyr215 and ...
Bo He, Yanhao Hu, Xu He, Wang Chen, Wei Yan, Xin Zang, Jiahai Zhou, Yonghao Ye   +7 more
wiley   +1 more source

Intra‐ and Intermolecular Glycosylation of d‐Idopyranosyl and 6‐Deoxy‐d‐ido‐heptopyranosyl Donors: Toward the Repeating Unit of Campylobacter jejuni HS:4c Capsular Polysaccharide

European Journal of Organic Chemistry, Volume 29, Issue 4, January 26, 2026.
A comprehensive glycosylation study of diversely protected and activated d‐idopyranosyl and 6‐deoxy‐d‐ido‐heptopyranosyl donors using intra‐ and intermolecular coupling strategies is reported. Intramolecular aglycon delivery afforded 1,2‐cis‐β‐idopyranosides, while intermolecular glycosylation yielded chromatographically separable α‐ and β‐linked ...
Maude Cloutier, Nitish Verma, Ilona Douchez, Charles Gauthier   +3 more
wiley   +1 more source

Synthesis of 2‐(Quinoxalin‐2‐yl)acetamides and Their Preliminary Cytotoxic and Antibacterial Activity

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Quinoxaline is an aza‐heterocycle found in some bioactive compounds. Thus, to enhance the pharmacological scope of this nucleus, we report a series of 19 acetamides decorated with a quinoxaline core. The synthesis involved the linkage of previously constructed bromoacetamides and hydroxyphenyl quinoxalines via an SN2 reaction. The first series
Cesar E. Tovar‐Roman, Eduardo Hernández‐Vázquez, José A. Rivera‐Chávez   +2 more
wiley   +1 more source

Non-chelation control in allylations of α-oxy ketones using group-14 allylatranes. [PDF]

Nat Commun
Tsutsui Y, Shiga K, Konishi A, Yasuda M.
europepmc   +1 more source

Reactive Carbonyl Species Mediate Isothiocyanate Signaling Pathway in Arabidopsis thaliana Guard Cells. [PDF]

Physiol Plant
Farzana S, Islam MM, Nakamura T, Nakamura Y, Munemasa S, Mano J, Murata Y.   +6 more
europepmc   +1 more source