Results 81 to 90 of about 358,966 (246)

Echocardiographic assessment of myocardial function and mechanics during veno-venous extracorporeal membrane oxygenation

Echo Research and Practice, 2019
Background: Transthoracic echocardiography (TTE) plays a fundamental role in the management of patients supported with extra-corporeal membrane oxygenation (ECMO). In light of fluctuating clinical states, serial monitoring of cardiac function is required.
David G Platts, Kenji Shiino, Jonathan Chan, Darryl J Burstow, Gregory M Scalia, John F Fraser   +5 more
doaj   +1 more source

A Generalization of Combinatorial Designs Related to Almost Difference Sets

, 2015
In this paper we study a certain generalization of combinatorial designs related to almost difference sets, namely the $t$-adesign, which was coined by Cunsheng Ding in 2015. It is clear that $2$-adesigns are a kind of partially balanced incomplete block design which naturally arise in many combinatorial and statistical problems.
Michel, Jerod, Ding, Baokun
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Repetition velocity during the leg and chest press in older adults: influence of starting execution technique

BMC Sports Science, Medicine and Rehabilitation
Background Effectively implementing velocity-monitored resistance training (RT) requires selecting appropriate methodologies, particularly in older adults.
Tiago Sousa, Ana Pereira, Diogo Luís Marques, Henrique Pereira Neiva, David Rodríguez-Rosell, Daniel Almeida Marinho, Mário Cardoso Marques   +6 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Bohr sets in sumsets III: expanding difference sets and almost Bohr sets

Let $G$ be a discrete abelian group. Følner showed that if $A \subseteq G$ has positive upper Banach density, then $A - A$ contains an almost Bohr set -- a set of the form $B \setminus E$ where $B$ is a Bohr set and $E$ has zero Banach density. We study the sets $S \subseteq G$ for which $A - A + S$ contains a Bohr set for every $A \subseteq G$ of ...
Bienvenu, Pierre-Yves, Griesmer, John T., Le, Anh N., Lê, Thái Hoàng   +3 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source