Results 101 to 110 of about 4,545,606 (290)

Almost Optimal Proper Learning and Testing Polynomials

open access: yes, 2022
We give the first almost optimal polynomial-time proper learning algorithm of Boolean sparse multivariate polynomial under the uniform distribution. For $s$-sparse polynomial over $n$ variables and $ε=1/s^β$, $β>1$, our algorithm makes $$q_U=\left(\frac{s}ε\right)^{\frac{\log β}β+O(\frac{1}β)}+ \tilde O\left(s\right)\left(\log\frac{1}ε\right)\log n$$
openaire   +2 more sources

Numerical Solution of an Optimal Control Problem with Probabilistic and almost Sure State Constraints

open access: yes
We consider the optimal control of a PDE with random source term subject to probabilistic or almost sure state constraints. In the main theoretical result, we provide an exact formula for the Clarke subdifferential of the probability function without a ...
Geiersbach, Caroline   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Estimates on the Bergman Kernels in a Tangential Direction on Pseudoconvex Domains in C3

open access: yesAbstract and Applied Analysis, 2018
Let Ω be a smoothly bounded pseudoconvex domain in C3 and assume that TΩreg(z0)
Sanghyun Cho
doaj   +1 more source

EVALUATION OF OPTIMAL HIGH DENSITY CHOLESTEROL VALUE IN COHORT OF ALMOST HEALTHY MEN 40-59 YEARS OLD (BY THE DATA OF 30-YEAR PROSPECTIVE OBSERVATION)

open access: yesКардиоваскулярная терапия и профилактика, 2015
Aim. To estimate the relation of the 30-year survival equation and levels of high-density cholesterol (HDL) in almost healthy men 40-59 years old and to define based on this data the optimal level of HDL for that category of persons.Material and methods.
V. V. Belov, A. A. Menshchikov
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Optimal allocation of clusters in stepped wedge designs with a decaying correlation structure

open access: yesPLoS ONE, 2023
The cluster randomized stepped wedge design is a multi-period uni-directional switch design in which all clusters start in the control condition and at the beginning of each new period a random sample of clusters crosses over to the intervention ...
Mirjam Moerbeek
doaj  

LIVING STANDARDS IN MODERN GERMANY

open access: yesВестник университета, 2019
This article reflects the main directions of achieving an optimal standard of living for German citizens, determines the main aspects of its maintenance.
L. D. Efanova, S. A. Shmukler
doaj   +1 more source

Stochastic Optimal Growth with Bounded or Unbounded Utility and with Bounded or Unbounded Shocks [PDF]

open access: yes
This paper studies a one-sector stochastic optimal growth model with i.i.d. productivity shocks in which utility is allowed to be bounded or unbounded, the shocks are allowed to be bounded or unbounded, and the production function is not required to ...
Takashi Kamihigashi
core  

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