Results 81 to 90 of about 656,245 (262)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Optimal quantum states for frequency estimation
New Journal of Physics, 2014 We investigate different quantum parameter estimation scenarios in the presence of noise, and identify optimal probe states. For frequency estimation of local Hamiltonians with dephasing noise, we determine optimal probe states for up to 70 qubits, and ...
F Fröwis +3 more
doaj +1 more source
Кардиоваскулярная терапия и профилактика, 2015 Aim. To estimate the relation of the 30-year survival equation and levels of high-density cholesterol (HDL) in almost healthy men 40-59 years old and to define based on this data the optimal level of HDL for that category of persons.Material and methods.
V. V. Belov, A. A. Menshchikov
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Optimal allocation of clusters in stepped wedge designs with a decaying correlation structure
PLoS ONE, 2023 The cluster randomized stepped wedge design is a multi-period uni-directional switch design in which all clusters start in the control condition and at the beginning of each new period a random sample of clusters crosses over to the intervention ...
Mirjam Moerbeek
doaj
LIVING STANDARDS IN MODERN GERMANY
Вестник университета, 2019 This article reflects the main directions of achieving an optimal standard of living for German citizens, determines the main aspects of its maintenance.
L. D. Efanova, S. A. Shmukler
doaj +1 more source
Robust empirical optimization is almost the same as mean–variance optimization
Operations Research Letters, 2017 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gotoh, Jun-ya +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source