Results 91 to 100 of about 6,403 (242)

Nanoformulated Diacerein Alleviates Hyperlipidemia via Gut Microbiota Modulation In Vivo

Nano Select, Volume 7, Issue 2, February 2026.
A nanoformulation of diacerein (Nano‐DIA) was fabricated with carboxymethyl cellulose, achieving enhanced solubility and rapid dissolution for alternative anti‐hyperlipidemia therapeutics. Mechanistic studies revealed its in vivo lipid‐lowering efficacy is through metabolite‐mediated and microbiota‐dependent manner, highlighting its dual action on host
Zheng Peng, Yi Yu, Mingyi Chen, Weibin Wu, Chunyan Zhu, Caisheng Wu, Weihua Li, Zehua Liu, Qiang Xie   +8 more
wiley   +1 more source

Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells [PDF]

, 2013
BACKGROUND: Multidrug resistance (MDR) is a major hurdle for cancer treatment worldwide and accounts for chemotherapy failure in over 90% of patients with metastatic cancer.
Armelle T Mbaveng, Benjamin Wiench, Igor K Voukeng, Roger Tsobou, Thomas Efferth, Veronique P Beng, Victor Kuete   +6 more
core   +1 more source

AIE‐Mediated In Situ Monitoring of Protein Aggregates During Coagulation and Screening of Anticoagulant Agents

Aggregate, Volume 7, Issue 1, January 2026.
The process of screening active monomers via BioSTAS technology. (A) Analyzing the properties and luminescence mechanism of an AIE molecule through density functional theory and MD simulation. (B) The establishment of a screening model, including biosensing and affinity chromatography. (C) Screening and identification of active substances.
Shuxian Zhang, Hui Yuan, Lingling Yang, Xiaoxuan Fan, Keshuai Liu, Rui Mai, Wangyan Zhao, Cheng Liu, Qiang Han, Yongjian Ai, Qionglin Liang, Xueqin Ma, Guoning Chen   +12 more
wiley   +1 more source

Aloe(-emodin) for cancer? More than just a comforting salve [PDF]

Cancer Biology & Therapy, 2007
Commentary to:Growth Inhibitory Effects of Gastric Cancer Cells with an Increase in S Phase and Alkaline Phosphatase Activity Repression by Aloe-emodinJunming Guo, Bingxiu Xiao, Shun Zhang, Donghai Liu, Yiping Liao and Qian ...
Jay F, Dorsey, Gary D, Kao
openaire   +2 more sources

In-Silico UHPLC Method Optimization for Aglycones in the Herbal Laxatives Aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Roots

Molecules, 2017
For the European Pharmacopoeia (Ph. Eur.) herbal monograph draft of Cassia angustifolia Vahl. and Cassia senna L. leaves and pods, a safety limitation of aloe-emodin and rhein was proposed, due to toxicological concerns. A quantitative, analytical method
Nadja Meier, Beat Meier, Samuel Peter, Evelyn Wolfram   +3 more
doaj   +1 more source

Mechanism of aloe emodin-induced apoptosis in ER+-breast cancer cells, MCF-7 / Indah Mohd Amin [PDF]

, 2017
Aloe emodin, an anthraquinone exhibits higher cytotoxicity to hepatoma, prostate and cervical cancer cells through cell cycle arrest and apoptosis compared to normal cells.
Mohd Amin, Indah
core  

Threading Granules in Freiburg : 2nd International Symposium on "One Mitochondrion, Many Diseases – Biological and Molecular Perspectives", a FRIAS Junior Researcher Conference, Freiburg im Breisgau, Germany, March 9th/10th, 2016 [PDF]

, 2016
Altered mitochondrial activities play an important role in many different human disorders, including cancer and neurodegeneration. At the Freiburg Institute of Advanced Studies (FRIAS) Junior Researcher Conference “One Mitochondrion, Many Diseases ...
Braun, Ralf J., Dumit, Verónica I., Gris, Denis, Steinberg, Florian, Zerbes, Ralf M.   +4 more
core   +2 more sources

Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang   +11 more
wiley   +1 more source

Interaction of aloe-emodin with human serum albumin

Chinese Science Bulletin, 2007
The presence of several high affinity binding sites on human serum albumin (HSA) makes it a possible target for many drugs. This study is designed to examine the effect of aloe-emodin on HSA by fluorescence, CD spectroscopy and molecular modeling. The results of fluorescence measurements suggested that the hydrophobic interaction was the predominant ...
JinFeng Du, Ying Li, Qi Zhang, XiaoJun Yao   +3 more
openaire   +1 more source

Pharmacokinetic Comparison in Rats of Six Bioactive Compounds between Decoction and its Parent Herbal Medicines

Natural Product Communications, 2010
Da-Cheng-Qi decoction (DCQD) is a purgative compound prescription used in China and East Asia. In this paper, pharmacokinetic differences of six major active components (rhein, emodin, aloe-emodin, magnolol, naringenin and hesperetin) between DCQD and ...
Fengguo Xu, Ying Liu, Haijuan Dong, Rui Song, Zunjian Zhang   +4 more
doaj   +1 more source