Results 101 to 110 of about 5,920 (134)

Failure of N‐Acetylcysteine to reduce alpha amanitin toxicity

Journal of Applied Toxicology, 1992
AbstractAcetaminophen undergoes toxic conversion in the liver to a free‐radical intermediary which binds to glutathione. N‐Acetylcysteine acts as a glutathione precursor when natural stores are depleted, and is an effective antidote for acetaminophen overdose.
S M, Schneider, E A, Michelson, G, Vanscoy   +2 more
openaire   +2 more sources

[Toxicity of alpha-amanitin on mice in vivo].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2010
To study the toxic effect of alpha-amanitin from Amanita fungi on mice in vivo.The LD50 of alpha-amanitin was determined with intravenous and intraperitoneal injections of alpha-amanitin. The mice were then injected intravenously with LD50 dose of alpha-amanitin, and the viscera index was evaluated.
Mei, Cao, Liang, Yan, Yuan-Yang, Nie, Zhi-Rong, Yang, Jian, Zhao   +4 more
openaire   +1 more source

Hemoperfusion with alpha-amanitin: an in vitro study.

The International journal of artificial organs, 1997
The authors carried out sixteen hemoperfusions with alpha-amanitin in vitro in a closed system using active charcoal, Amberlite XAD-2 and Amberlite XAD-4 in hemoperfusion capsules. As a perfusion solution 4 liters of 0.9% NaCl solution was used. The alpha-amanitin concentration in the solution was 8.3 +/- 0.36 mg/L.
M, Mydlík, K, Derzsiová, J, Klán, T, Zíma   +3 more
openaire   +1 more source

alpha-Amanitin resistant RNA polymerase II from Aedes albopictus cell mutants resistant to alpha-amanitin.

Cell biology international reports, 1980
Spontaneous and EMS-induced alpha-amanitin-resistant Aedes albopictus cells have been isolated and characterized. Two mutant sublines, one of intermediate resistance (alpha A2) and the other highly resistant (Ama18) contained RNA polymerase II activity, the resistance of which in vitro to alpha-amanitin correlated well with the resistance of these ...
S J, Mento, V, Stollar
openaire   +1 more source

Effects of resveratrol on alpha-amanitin-induced nephrotoxicity in BALB/c mice

Human & Experimental Toxicology, 2019
Alpha-amanitin (α-AMA), the primary toxin of Amanita phalloides, is known to cause nephrotoxicity and hepatotoxicity. Resveratrol is an antioxidant that has shown efficacy in many nephrotoxicity models. The aim of this study was to investigate the effects of resveratrol against the early and late stages of α-AMA-induced nephrotoxicity, compared to ...
MA Arici, A Sahin, Z Cavdar, BU Ergur, C Ural, P Akokay, S Kalkan, Y Tuncok   +7 more
openaire   +3 more sources

Stability of ricinine, abrine, and alpha-amanitin in finished tap water

Analytical Methods, 2013
Ricinine and abrine are potential indicators of drinking water contamination by ricin and abrin, respectively. Simultaneous detection of ricinine and abrine, along with α-amanitin, another potential biotoxin water contaminant, is reportable through the use of automated sample preparation via solid phase extraction and detection using liquid ...
Jennifer S. Knaack, Christopher T. Pittman, Joe V. Wooten, Justin T. Jacob, Matthew Magnuson, Erin Silvestri, Rudolph C. Johnson   +6 more
openaire   +1 more source

Use of amifostine, a novel cytoprotective, in alpha-amanitin poisoning.

Clinical toxicology (Philadelphia, Pa.), 2005
Mortality from ingestions of the mushroom Amanita phalloides remains as high as 20-40% with many surviving patients requiring liver transplantation. A variety of treatments for Amanita ingestion have been evaluated, yet other than supportive measures, no effective therapy has been identified.
Brandon K, Wills, Nairmeen Awad, Haller, David, Peter, Lynn J, White   +3 more
openaire   +1 more source

The action of silybin on the mouse liver in alpha-amanitine poisoning.

Arzneimittel-Forschung, 1979
Histochemical and histoenzymological studies were carried out on liver slices from mice which had received alpha-amanitine two days previously, some of which had been treated with silybin, and from control mice. The toxin produced certain changes in the activity of the enzymes involved in different metabolic processes, and in the amounts of lipids and ...
J, Choppin, A, Desplaces
openaire   +1 more source

Erdosteine reduces cytotoxicity induced by alpha- and beta-amanitin, but not gamma-amanitin, in CA3 hepatocyte cultures

Toxicon, 2022
Ismail Yilmaz, Ertugrul Kaya, Recep Bayram   +2 more
exaly  

Thioctic Acid in the Treatment of Poisoning. with Alpha-Amanitin

2020
F C Bartter, B Berkson, J Galle, Ii, P Hiranaka   +4 more
openaire   +1 more source