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Timing and phenotype in refining the role of plasma exchange in amatoxin-induced acute liver failure. [PDF]
Crit CareÖzden Y, Gökçe DT.
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Alpha-amanitin-concanavalin A conjugates as inhibitors of specific cell types /
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Aucubin: Potential Antidote For Alpha-Amanitin Poisoning
Journal of Toxicology: Clinical Toxicology, 1984Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50% survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration.
L M, Chang, H S, Yun, Y S, Kim, J W, Ahn
exaly +3 more sources
Sensitivity of alpha-amanitin to oxidation by a lactoperoxidase-hydrogen peroxide system
Toxicon, 2000Oxidation of alpha-amanitin - a potent hepatotoxin found in the mushroom Amanita phalloides - by a lactoperoxidase-hydrogen peroxide system was investigated by different techniques. (i). UV spectroscopy of the mixture after 24 h incubation reveals a significant decrease in the absorbance range characteristic of the putative reactive moiety of the toxin,
Antoaneta Zheleva, D Michelot
exaly +4 more sources
Evaluation of the genotoxicity of alpha-amanitin in mice bone marrow cells
Toxicon, 2017Alpha-amanitin is a known cytotoxic substance found in some mushroom species including Amanita phalloides. Its main mechanism of action is to block the transcription, which can lead to cell death. Lack of reports on the genotoxicity of this toxin was an inspiration for undertaking this experiment.
B, Marciniak +2 more
exaly +3 more sources
Biodistribution of radiolabeled alpha-amanitin in mice: An Investigation
ToxiconMushroom poisonings caused by Amanita phalloides are the leading cause of mushroom-related deaths worldwide. Alpha-Amanitin (α-AMA), a toxic substance present in these mushrooms, is responsible for the resulting hepatotoxicity and nephrotoxicity. The objective of our study was to determine the distribution of α-AMA in Balb/c mice by labeling with ...
Elif Baris +2 more
exaly +4 more sources
Toxicon, 2018
Amanitin-induced apoptosis is proposed to have a significant effect on the pathogenesis of liver damage. However, few reports have focused on proteome changes induced by α-amanitin (α-AMA). Here, we evaluated changes in mitochondrial proteins of hepatocytes in response to 2 μM α-AMA, a concentration at which α-AMA-induced cell damage could be rescued ...
Ping Chen, Zuohong Chen
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Amanitin-induced apoptosis is proposed to have a significant effect on the pathogenesis of liver damage. However, few reports have focused on proteome changes induced by α-amanitin (α-AMA). Here, we evaluated changes in mitochondrial proteins of hepatocytes in response to 2 μM α-AMA, a concentration at which α-AMA-induced cell damage could be rescued ...
Ping Chen, Zuohong Chen
exaly +3 more sources
Dermal absorption and toxicity of alpha amanitin in mice
Cutaneous and Ocular Toxicology, 2013The fungus Amanita phalloides is known to contain two main groups of toxins: amanitins and phallotoxins. The amanitins group effectively blocks the RNA polymerase II enzyme found in eukaryotic cells. As alpha amanitin has a lethal effect on the majority of eukaryotic cells, it can be valuable as an antiparasitic or antifungal drug.
Ertugrul, Kaya +7 more
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