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A Meta-Analysis of Synovial Biomarkers in Periprosthetic Joint Infection: Synovasure™ Is Less Effective Than the ELISA-Based Alpha-Defensin Test [PDF]

Knee Surgery, Sports Traumatology, Arthroscopy, 2018
PURPOSE (1) To determine the overall accuracy of synovial alpha-defensin, synovial C-reactive protein (sCRP), interleukin-6 (sIL-6), and leukocyte esterase (sLE) as diagnostic markers for periprosthetic joint infection (PJI) and (2) to independantly ...
Sufian Ahmad, Sandro Kohl, Sithombo Maqungo   +2 more
exaly   +4 more sources

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The Routine Use of Synovial Alpha-Defensin Is Not Necessary

Bone and Joint Journal, 2020
Aims To establish the utility of adding the laboratory-based synovial alpha-defensin immunoassay to the traditional diagnostic work-up of a prosthetic joint infection (PJI). Methods A group of four physicians evaluated 158 consecutive patients who were worked up for PJI, of which 94 underwent revision arthroplasty.
Robin Z Cheng, Stuart Goodman, Derek F Amanatullah   +2 more
exaly   +3 more sources

A profile on the Synovasure alpha defensin test for the detection of periprosthetic infections

Expert Review of Molecular Diagnostics, 2020
Clinicians have waited a long time for a 'universal' marker that may help them distinguish infected from non-infected total joint arthroplasties when doubts persist after using classical clinical and biological signs of infection. In recent years, synovial fluid biomarkers including leukocyte esterase, alpha-defensins, and CRP have shown promising ...
Senneville, Eric, Robineau, Olivier, Loiez, Caroline, de Saint Vincent, Benoit, Dartus, Julien, Migaud, Henri   +5 more
openaire   +3 more sources

Expression of alpha‐defensin‐1 in chronic hyperplastic candidosis

Journal of Oral Pathology & Medicine, 2005
Background:  Chronic hyperplastic candidosis (CHC) represents a chronic opportunistic candida infection. We clarified the presence, localization and participation of α‐defensin‐1 in host response against chronic candidal stimulus.Methods:  Immunohistochemically stained CHC biopsies (n = 10) were compared to candida negative idiopathic leukoplakia (n ...
Ali, Ahmed, Niissalo, Sirkku, Hietanen, Jarkko, Laine, Mikael, Richardson, Rautemaa-Richardson; id_orcid 0000-0002-1071-6040, Konttinen, Yrjö   +5 more
openaire   +3 more sources

Alpha-Defensin-1 in Synovial Fluid Is Useful for Diagnosis of Joint Infection

Journal of UOEH, 2020
The distinction between bacterial infectious and noninfectious arthritis is typically challenging in the early stages; however, it is critical for treatment decision making. Here, we investigated the diagnostic relevance of alpha- and beta-defensin levels in serum and synovial fluid as biomarkers of joint infection in patients presenting with fever and
Makoto Kawasaki, Yoshiaki Yamanaka, Akinori Sakai   +2 more
exaly   +4 more sources

Validation of the Alpha Defensin Lateral Flow Test for Periprosthetic Joint Infection

Journal of Bone and Joint Surgery, 2020
Background: The synovial fluid test for alpha defensin has been reported to have an excellent performance in diagnosing periprosthetic joint infection (PJI). The purpose of this study was to evaluate the performance of the lateral flow test for synovial fluid alpha defensin by using the methods of a formal ...
Carl Deirmengian, John Madigan, Sujith Kallur Mallikarjuna, Janet Conway, Carlos Higuera, Robin Patel   +5 more
openaire   +2 more sources

Synovial fluid alpha-defensins in Lyme arthritis—a useful marker

Folia Microbiologica
Lyme arthritis, one of the possible late manifestations of Lyme borreliosis, predominantly affects the supporting joints and in adults most often occurs in the form of monoarthritis of the knee. Early diagnosis is based on clinical findings and serology.
Pavel Melicherčík, Matěj Mazura, Martin Hodík, Kamila Dundrová, Ivan Landor, David Jahoda, Rudolf Horváth, Vladislav Barták, René Kizek, Eva Klapková   +9 more
openaire   +2 more sources

Metabolic Modulation of Bacterial Resistance to Alpha-Defensins

2017
Alpha-defensins are broad-spectrum antimicrobial peptides secreted by Paneth cells of the intestinal epithelium, as a part of host innate immune defense. However, specific groups of bacteria are able to inhabit the intestinal lumen despite the antimicrobial pressure exerted by alpha-defensins.
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Alpha-Defensin Overexpression in Patients with Bell's Palsy and Ramsay Hunt Syndrome

Annals of Otology, Rhinology & Laryngology, 2012
Objectives: To investigate the biological factors related to the onset of Bell's palsy, we sought to identify differentially expressed genes in peripheral blood mononuclear cells (PBMCs) and plasma of patients with Bell's palsy and Ramsay Hunt syndrome (RHS).
Yasushi, Furuta, Nobuhiko, Oridate, Norihito, Takeichi, Satoshi, Fukuda, Hirofumi, Sawa   +4 more
openaire   +2 more sources