Results 161 to 170 of about 9,164 (193)

Trans-kingdom conservation of mechanism between bacterial actifensin and eukaryotic defensins. [PDF]

NPJ Antimicrob Resist
Sugrue I, Ade C, O'Connor PM, Daniel JM, Innocenti P, Kirsch N, Martin NI, Weindl G, Hill C, Schneider T, Paul Ross R.   +10 more
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Alpha-defensins promote macrophage inflammatory activation via RNF31 signaling

Genes and Genomics
Defensins, small cationic peptides with strong antimicrobial activity, are key effectors of innate immunity. α-defensins, human neutrophil peptides, are produced primarily by neutrophils and serve as an essential component of the airway defense system against invading pathogens.
Jungnam Lee, Naweed Mohammad, Seyoung Mun   +2 more
exaly   +3 more sources

VP4 Is a Determinant of Alpha-Defensin Modulation of Rotaviral Infection

Journal of Virology, 2022
Rotavirus is a leading cause of severe diarrhea in young children. Like other fecal-oral pathogens, rotaviruses encounter abundant, constitutively expressed defensins in the small intestine.
Ciara T. Hu, Karina Diaz, Linda C. Yang, Anjali Sharma, Harry B. Greenberg, Jason G. Smith   +5 more
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The routine use of synovial alpha-defensin is not necessary

The Bone & Joint Journal, 2020
Aims To establish the utility of adding the laboratory-based synovial alpha-defensin immunoassay to the traditional diagnostic work-up of a prosthetic joint infection (PJI). Methods A group of four physicians evaluated 158 consecutive patients who were worked up for PJI, of which 94 underwent revision arthroplasty.
Derek F, Amanatullah, Robin Z, Cheng, James I, Huddleston Iii, William J, Maloney, Andrea K, Finlay, Shanthi, Kappagoda, Gina A, Suh, Stuart B, Goodman   +7 more
openaire   +2 more sources

A profile on the Synovasure alpha defensin test for the detection of periprosthetic infections

Expert Review of Molecular Diagnostics, 2020
Clinicians have waited a long time for a 'universal' marker that may help them distinguish infected from non-infected total joint arthroplasties when doubts persist after using classical clinical and biological signs of infection. In recent years, synovial fluid biomarkers including leukocyte esterase, alpha-defensins, and CRP have shown promising ...
Senneville, Eric, Robineau, Olivier, Loiez, Caroline, de Saint Vincent, Benoit, Dartus, Julien, Migaud, Henri   +5 more
openaire   +3 more sources

Expression of alpha‐defensin‐1 in chronic hyperplastic candidosis

Journal of Oral Pathology & Medicine, 2005
Background:  Chronic hyperplastic candidosis (CHC) represents a chronic opportunistic candida infection. We clarified the presence, localization and participation of α‐defensin‐1 in host response against chronic candidal stimulus.Methods:  Immunohistochemically stained CHC biopsies (n = 10) were compared to candida negative idiopathic leukoplakia (n ...
Ali, Ahmed, Niissalo, Sirkku, Hietanen, Jarkko, Laine, Mikael, Richardson, Rautemaa-Richardson; id_orcid 0000-0002-1071-6040, Konttinen, Yrjö   +5 more
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Synovial fluid alpha-defensin in periprosthetic knee infection workup : liquid chromatography-mass spectrometry detection of alpha-defensin in synovial fluid.

The bone & joint journal, 2022
The diagnosis of periprosthetic joint infection (PJI) continues to present a significant clinical challenge. New biomarkers have been proposed to support clinical decision-making; among them, synovial fluid alpha-defensin has gained interest. Current research methodology suggests reference methods are needed to establish solid evidence for use of the ...
Balato, Giovanni, Dall'Anese, Riccardo, Balboni, Fiamma, Ascione, Tiziana, Pezzati, Paola, Bartolini, Giuseppe, Quercioli, Massimo, Baldini, Andrea   +7 more
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Validation of the Alpha Defensin Lateral Flow Test for Periprosthetic Joint Infection

Journal of Bone and Joint Surgery, 2020
Background: The synovial fluid test for alpha defensin has been reported to have an excellent performance in diagnosing periprosthetic joint infection (PJI). The purpose of this study was to evaluate the performance of the lateral flow test for synovial fluid alpha defensin by using the methods of a formal diagnostic accuracy ...
Carl Deirmengian, John Madigan, Sujith Kallur Mallikarjuna, Janet Conway, Carlos Higuera, Robin Patel   +5 more
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Synovial fluid alpha-defensins in Lyme arthritis—a useful marker

Folia Microbiologica
Lyme arthritis, one of the possible late manifestations of Lyme borreliosis, predominantly affects the supporting joints and in adults most often occurs in the form of monoarthritis of the knee. Early diagnosis is based on clinical findings and serology.
Pavel Melicherčík, Matěj Mazura, Martin Hodík, Kamila Dundrová, Ivan Landor, David Jahoda, Rudolf Horváth, Vladislav Barták, René Kizek, Eva Klapková   +9 more
openaire   +2 more sources