Results 171 to 180 of about 9,164 (193)
Some of the next articles are maybe not open access.
Metabolic Modulation of Bacterial Resistance to Alpha-Defensins
2017Alpha-defensins are broad-spectrum antimicrobial peptides secreted by Paneth cells of the intestinal epithelium, as a part of host innate immune defense. However, specific groups of bacteria are able to inhabit the intestinal lumen despite the antimicrobial pressure exerted by alpha-defensins.
openaire +2 more sources
Alpha-Defensin Overexpression in Patients with Bell's Palsy and Ramsay Hunt Syndrome
Annals of Otology, Rhinology & Laryngology, 2012Objectives: To investigate the biological factors related to the onset of Bell's palsy, we sought to identify differentially expressed genes in peripheral blood mononuclear cells (PBMCs) and plasma of patients with Bell's palsy and Ramsay Hunt syndrome (RHS).
Yasushi, Furuta +4 more
openaire +2 more sources
Alpha-defensins in the prevention of HIV transmission among breastfed infants.
Journal of acquired immune deficiency syndromes (1999), 2005Alpha-defensins have been observed to have anti-HIV activity but have not been investigated in relation to mother-to-child HIV transmission. We measured the concentration of alpha-defensins in breast milk of HIV-positive mothers and tested whether the concentrations were associated with HIV transmission.
L. Kuhn +11 more
openaire +2 more sources
[Structure and function of enteric alpha defensins in norm and pathology].
Molekuliarnaia biologiia, 2012This review summarizes currently available data on enteric alpha defensins structure, their functions in the innate and adaptive immunity systems and the role in development of intestinal illnesses.
I G, Nikitina +6 more
openaire +1 more source
The Molecular Determinants of Human alpha-Defensins' Biological Functions.
2010Human alpha-defensins are cationic peptides with potent antitoxic, antimicrobial and chemotactic activities in the innate and adaptive immunity. Bacillus anthracis produces a lethal factor [LF], which is a potent toxin, capable of cell lysis. The molecular mechanism of the inhibition of LF by human alpha-defensins and the bacterial strain selectivity
openaire +1 more source
α-Defensins in the gastrointestinal tract
Molecular Immunology, 2003The human intestinal tract is constantly exposed to an enormous indigenous bacterial flora. It has recently been recognised that antimicrobial peptides of the defensin family likely play a role in protection against microbial invasion at a variety of mucosal epithelial surfaces, including that of the intestinal tract.
openaire +2 more sources
Alpha defensin expression in white blood cells
2019Copy number variation (CNV) accounts for a large proportion of genetic variation. The DEFA1A3 CNV has variable numbers of copies of the DEFA1 and DEFA3 genes that encode alpha defensins 1-3, antimicrobial peptides abundant in human neutrophils.
openaire +1 more source
Human alpha defensin CNV haplotype diversity
2018Humans have highly variable number of alpha defensin genes, with between 3-16 diploid copies. Alpha-defensin genes have important roles in human innate immunity and diseases. Recently, GWAS studies reported this locus associated with IgA nephropathy and periodontitis. However, the underlying mechanism of association is not clear. In this Ph.D.
openaire +1 more source
Synovial alpha-defensin in native joints with inflammatory arthropathies
Zeitschrift für Orthopädie und Unfallchirurgie, 2020NM Jandl +4 more
openaire +1 more source