Results 1 to 10 of about 46,608 (304)

Molecular Structure-Based Screening of the Constituents of Calotropis procera Identifies Potential Inhibitors of Diabetes Mellitus Target Alpha Glucosidase

Current Issues in Molecular Biology, 2022
Diabetes mellitus is a disorder characterized by higher levels of blood glucose due to impaired insulin mechanisms. Alpha glucosidase is a critical drug target implicated in the mechanisms of diabetes mellitus and its inhibition controls hyperglycemia ...
Cynthia A. Adinortey, Gabriel B. Kwarko, Russell Koranteng, Daniel Boison, Issaka Obuaba, Michael D. Wilson, Samuel K. Kwofie   +6 more
doaj   +1 more source

Comprehensive Analysis on Cotinus Coggygria Scop. Leaves: Phytochemical Characterization, Biological Profile and Docking Studies

Studia Universitatis Babes-Bolyai Chemia, 2023
The present work aims to evaluate the antioxidant, cytotoxic, enzyme inhibitory, and anti-inflammatory properties of Cotinus coggygria Scop. The leaf extract was analyzed using LC-MS/MS and antioxidant activity was also investigated via several in vitro
Gökçe ŞEKER KARATOPRAK, Gökçen KILIÇ, İsmail ÇELIK, Selen İLGÜN, Esra KÖNGÜL ŞAFAK, Müberra KOŞAR   +5 more
doaj   +1 more source

Insight into the Alpha-Glucosidase Inhibitory Potentials of Curcuma longa Methanolic Extracts and Phytochemicals: An In Vitro and In Silico Study

Biology and Life Sciences Forum, 2023
Diabetes is a metabolic disease of global concern, causing death due to triggered oxidative and inflammatory complications. Alpha-glucosidase has become a popular drug target for managing diabetes.
Ada-Jesus Mercy Okechukwu, Emmanuel Sunday Okeke, Kingsley Nnaechetam Eze, Wisdom Favour Chinedu Ezeorba, Timothy Prince Chidike Ezeorba   +4 more
doaj   +1 more source

Molecular Docking and Dynamic Diterpenoid-Stevia Compounds from Water Maceration-Sonification Extract as Amylase and Glucosidase Enzyme Inhibits [PDF]

Brazilian Archives of Biology and Technology
Stevia (Stevia rebaudiana), with its intense sweetness, therapeutic properties, and safety profile, serves not only as a sugar substitute but also promotes holistic metabolic health.
Sentot Joko Raharjo, Teti Estiasih, Ernanin Dyah Wijayanti, Dewi Ratih Tirto Sari, Yantty Maryanty   +4 more
doaj   +1 more source

Study of synergistic Inhibitory effectiveness of mixed of Sweet bell pepper extract and virgin olive oil in α -amylase and α-glucosidase activity in serum of male rats infected with experimental diabetes

Tikrit Journal of Pure Science, 2023
The present research designed for evaluate the inhibitory activities of red bell pepper alone ,red bell pepper and virgin olive oil together on alpha-amylase and alpha-glucosidase activities of adult male rats (Rattus norvegicus) infected with ...
Wedad M. Lahmood Al-obaidi
doaj   +1 more source

Alpha-glucosidase Inhibitors

JPMA. The Journal of the Pakistan Medical Association, 2014
Alpha glucosidase inhibitors (AGIs) are a unique class of anti-diabetic drugs. Derived from bacteria, these oral drugs are enzyme inhibitors which do not have a pancreato -centred mechanism of action. Working to delay carbohydrate absorption in the gastrointestinal tract, they control postprandial hyperglycaemia and provide unquestioned cardiovascular ...
Sanjay Kalra, Jaikrit Bhutani
openaire   +3 more sources

Starch biotransformation into isomaltooligosaccharides using thermostable alpha-glucosidase from Geobacillus stearothermophilus [PDF]

PeerJ, 2018
The present study first identified the biotransformation of starch as a novel preparation method was investigated using the alpha-transglucosidase-producing Geobacillus stearothermophilus U2. Subsequently, 5 L- and 20 L-scale fermentations were performed.
Peng Chen, Ruixiang Xu, Jianhui Wang, Zhengrong Wu, Lei Yan, Wenbin Zhao, Yuheng Liu, Wantong Ma, Xiaofeng Shi, Hongyu Li   +9 more
doaj   +2 more sources

Comparison of Phytochemical Differences of the Pulp of Different Peach [Prunus persica (L.) Batsch] Cultivars with Alpha-Glucosidase Inhibitory Activity Variations in China Using UPLC-Q-TOF/MS

Molecules, 2019
In order to fully understand the variation of the fruit alpha-glucosidase inhibitory activity-related phytochemical basis in the Chinese peach [Prunus persica (L.) Batsch], mature fruit from 33 cultivars was used for the investigation of fruit phenolic ...
Xianan Zhang, Mingshen Su, Jihong Du, Huijuan Zhou, Xiongwei Li, Xin Li, Zhengwen Ye   +6 more
doaj   +1 more source

Gene set enrichment analysis of alpha-glucosidase inhibitors from Ficus benghalensis

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To identify alpha-glucosidase inhibitors from Ficus benghalensis and analyze gene set enrichment of regulated protein molecules. Methods: The phytoconstituents of Ficus benghalensis were queried for inhibitors of alpha-glucosidase, also ...
Pukar Khanal, B M Patil
doaj   +1 more source

Effect of Green and Red Thai Kratom (Mitragyna speciosa) on pancreatic digestive enzymes (alpha-glucosidase and lipase) and acetyl-carboxylase 1 activity: A possible therapeutic target for obesity prevention.

PLoS ONE, 2023
Regular use of Thai kratom has been linked to reduced blood triglyceride levels and body mass index (BMI) in healthy individuals. We analyzed Green Thai Kratom (GTK) and Red Thai Kratom (RTK) to investigate their effects on pancreatic digestive enzymes ...
Atikarn Janthongkaw, Sirinthip Klaophimai, Tanaporn Khampaya, Supaporn Yimthiang, Yilin Yang, Ruixue Ma, Apirak Bumyut, Phisit Pouyfung   +7 more
doaj   +1 more source