Results 91 to 100 of about 225,346 (287)
Peroxisomes and disease - an overview. [PDF]
, 2016 Peroxisomes are indispensable for human health and development. They represent ubiquitous subcellular organelles which compartmentalize enzymes responsible for several crucial metabolic processes such as β-oxidation of specific fatty acids, biosynthesis ...
Bonekamp, NA, Delille, HK, Schrader, M
core
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
멜라토닌과 피탄산 처리에 따른 돼지 난자 및 배아 내 Nuclear factor erythroid-2-related factor 2 기전 및 퍼옥시좀 활성의 관계 분석 [PDF]
, 2021 학위논문 (박사) -- 서울대학교 대학원 : 수의과대학 수의학과, 2021. 2. 윤화영.돼지는 장기의 크기 및 생리학적 부분에서 인간과 매우 흡사하여 질병모델 및 이종장기 이식에 있어서 필수불가결한 종으로 꼽히고 있다. 또한 돼지는 다태종으로서, 연구자들에게 비교적 쉬운 접근성을 제공한다. 이러한 연구에 있어서 돼지의 체외생산은 중추적이고, 세분화 시 난자의 체외성숙과 배아의 체외배양으로 나뉘게 된다.
김의현
core
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Journal of Lipid Research, 1989 The hydroxylation of lithocholic acid (3 alpha-hydroxy-5 beta-cholanoic acid) by adult male Sprague-Dawley rat liver microsomes supplemented with NADPH was studied.
P Zimniak +4 more
doaj +1 more source
Effects of in vivo 3-iodothyronamine administration on gene expression in adipose tissue. [PDF]
, 2012 Thyroid hormones (THs) control the adipose tissue development and metabolism. They regulate both adipocyte proliferation and differentiation and, as they cause weight loss by increasing the metabolic rate, may be useful for obesity treatment.
MARIOTTI, VERONICA
core
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Alpha-pinene oxidation by OH: simulations of laboratory experiments [PDF]
Atmospheric Chemistry and Physics, 2004 This paper presents a state-of-the-art gas-phase mechanism for the degradation of α-pinene by OH and its validation by box model simulations of laboratory measurements. It is based on the near-explicit mechanisms for the oxidation of α-pinene
M. Capouet +3 more
doaj
Journal of Lipid Research, 1992 Much data has accumulated supporting a proatherogenic role for oxidized low density lipoprotein (Ox-LDL). Micronutrient antioxidants such as alpha-tocopherol, the principal lipid-soluble antioxidant, assume potential significance because levels can be ...
I Jialal, SM Grundy
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source