Results 221 to 230 of about 68,100 (329)

Perampanel Blocks Transsynaptic α‐Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease

Movement Disorders, EarlyView.
Abstract Background Transsynaptic α‐synuclein propagation plays a crucial role in the progression of Lewy body disease. We previously demonstrated that an α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, perampanel, blocks neuronal uptake of α‐synuclein preformed fibrils (PFFs) in an activity‐dependent manner.
Jun Ueda, Norihito Uemura, Jiarui Chang, Tetsuya Hirato, Tomoyuki Ishimoto, Miki Oono, Shuichi Matsuzawa, Riki Matsumoto, Hodaka Yamakado, Ryosuke Takahashi   +9 more
wiley   +1 more source

Alpha-synuclein seeding activity in postmortem tissues from patients with diffuse and isolated Lewy bodies. [PDF]

Acta Neuropathol Commun
Baranová S, Matěj R, Soukup J, Dušek P, Holada K.   +4 more
europepmc   +1 more source

Interaction of manganese with striatal dopamine turnover in human alpha-synuclein transgenic mice [PDF]

, 2010
Tamara M. Peneder, Michael L. Berger, Petra Scholze, Georg Heinze, Johanna Bertl, Jan Bauer, Oleh Hornykiewicz, Eric K. Richfield, Christian Pifl   +8 more
openalex   +1 more source

Types of Pain in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Pain affects up to 87% of people with multiple system atrophy (MSA), but it remains unclear which types of pain contribute most to the overall burden. Objective To estimate the frequency of different types of pain in MSA individuals.
Nicole Campese, Mubasher A. Qamar, Maria Alexandra Chiriac, Georg Göbel, Julia Wanschitz, Andreas Schlager, Bianca Caliò, Fabian Leys, Pam Bower, Laura Zamarian, Anette Schrag, Roy Freeman, Horacio Kaufmann, Roberta Granata, Stefan Kiechl, Werner Poewe, Klaus Seppi, Gregor Wenning, K. Ray Chaudhuri, Alessandra Fanciulli   +19 more
wiley   +1 more source

Synphilin-1 modulates alpha-synuclein assembly, release and uptake. [PDF]

NPJ Parkinsons Dis
Lázaro DF, Amen T, Gerhardt E, Song C, Burns R, Kruse N, Santos PI, Milovanovic D, Höglinger G, Mollenhauer B, Luk KC, Lee VM, Outeiro TF.   +12 more
europepmc   +1 more source

Ow940 Zgis128[P(Dat-1)::Alpha-Synuclein::Yfp] | 2014-04-16T14:23:31+02:00

, 2018
Céline N. Martineau, Ellen A. A. Nollen
openalex   +1 more source

Breaking Bad - Phospholipase Cβ Disrupts Alpha-Synuclein Aggregation in Neuronal Cells [PDF]

, 2013
Suzanne Scarlata, Yuanjian Guo
openalex   +1 more source

Clinical and Imaging Characteristics of Parkinson's Disease with Negative Alpha‐Synuclein Seed Amplification Assay

Movement Disorders, EarlyView.
Abstract Background The cerebrospinal fluid alpha‐synuclein seed amplification assay (CSFasynSAA) detects alpha‐synuclein aggregation in over 90% of individuals with sporadic PD (sPD). However, the clinical characteristics of sPD with negative CSFasynSAA remain undefined.
Sarah M. Brooker, Jacopo Pasquini, Seung Ho Choi, David‐Erick Lafontant, Seyed‐Mohammad Fereshtehnejad, Yashar Zeighami, Piergiorgio Grillo, Giulietta M. Riboldi, Houman Azizi, Roqaie Moqadam, Un Jung Kang, Kelly N.H. Nudelman, Andrew Siderowf, Caroline M. Tanner, Thomas F. Tropea, Tatiana Foroud, Lana M. Chahine, Brit Mollenhauer, Kalpana M. Merchant, Douglas Galasko, Christopher S. Coffey, Roseanne D. Dobkin, Ethan G. Brown, Roy N. Alcalay, Daniel Weintraub, Kenneth Marek, Tanya Simuni, Paulina Gonzalez‐Latapi, Nicola Pavese, Kathleen L. Poston, the Parkinson's Progression Markers Initiative   +30 more
wiley   +1 more source

The extent of alpha-synuclein aggregate accumulation in neurons varies depending on the type of neurotransmitter they release. [PDF]

Sci Rep
Kameda H, Okamoto S, Ogasawara K, Okuzumi A, Hattori N, Hioki H, Koike M.   +6 more
europepmc   +1 more source

Ow939 Zgis113[P(Dat-1)::Alpha-Synuclein::Yfp] | 2014-03-24T12:04:21+01:00

, 2018
Céline N. Martineau, Ellen A. A. Nollen
openalex   +1 more source