Results 221 to 230 of about 1,144,970 (369)
Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
Mass Spectrometry Reviews, EarlyView.ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu +4 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Isolated RBD (iRBD) is a prominent early marker of Parkinson's disease and related disorders. Objectives Evaluate biomarkers of inflammation and axonal damage people with iRBD for disease progression. Methods Plasma samples from 27 video‐polysomnography confirmed iRBD patients and 25 controls were analyzed for inflammatory ...
Brook Huxford +6 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Background The determinants of the severity of idiopathic normal pressure hydrocephalus (iNPH) have not been examined previously. Objective To reveal the clinical determinants of the clinical severity of iNPH in detail. To provide some clinical remarks and contributions to the understanding of the pathophysiology.
Halil Onder +3 more
wiley +1 more source
711. Alpha-Synuclein Gene Silencing by Adeno-Associated Viral Vector-Mediated Delivery of a Specific shRNA in the Substantia Nigra Results in Reduced Tyrosine Hydroxylase Immunoreactivity [PDF]
, 2008 openalex +1 more source
Basal Forebrain Volume Predicts Disease Conversion in Prodromal Synucleinopathy
Movement Disorders Clinical Practice, EarlyView.Abstract Background Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The basal forebrain (BF), a key cholinergic structure, is a site of known pathology in later stages of Lewy body disorders.
Lachlan Churchill +5 more
wiley +1 more source
Investigations of Amyloid Fiber Formation of Alpha-Synuclein and Amyloid-beta Using Newly Synthesized Small Molecules [PDF]
, 2009 Eric Y. Hayden +3 more
openalex +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Dream enactment behavior is a common feature of rapid eye movement (REM) sleep behavior disorder (RBD); however, there has been surprisingly little focus on sex differences in dream characterization in RBD. This is important to evaluate further, as it is possible that females and males have different dream characteristics in RBD ...
Samantha Bramich +8 more
wiley +1 more source
Atomistic and Coarse-grained MD study on mutated alpha-Synuclein in Water Box [PDF]
, 2009 Hongyi Yang +2 more
openalex +1 more source
Movement Disorders Clinical Practice, EarlyView.ABSTRACT Background Postural abnormalities (PA) can complicate Parkinson's disease (PD). While age and motor severity are established predictors, the genetic role remains underexplored. Objective To evaluate the influence of major genetic variants on PA development in PD over 4 years.
Ilaria A. Di Vico +6 more
wiley +1 more source