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Alpha-synuclein overexpression model.
Journal of neural transmission. Supplementum, 2006To elucidate the role of alpha-synuclein in the pathogenesis of Parkinson's disease (PD), both human alpha-synuclein transgenic mice and targeted overexpression of human alpha-synuclein in rat substantia nigra (SN) by viral vector-based methods have been studied, however little is known about the pathogenetic changes of dopaminergic neuron loss ...
H, Mochizuki, M, Yamada, Y, Mizuno
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Neurobiology of alpha-synuclein.
Molecular neurobiology, 2004Alpha-synuclein is an abundant neuronal protein that has been linked both to normal synaptic function and to neurodegeneration. Most significantly, mutations in the gene encoding for alpha-synuclein are responsible for Parkinson's disease (PD) in rare familial cases, and the aggregated protein is a major component of Lewy bodies found in sporadic PD ...
Kostas, Vekrellis +2 more
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Deamidation of alpha-synuclein.
Protein science : a publication of the Protein Society, 2009The rates of deamidation of alpha-synuclein and single Asn residues in 13 Asn-sequence mutants have been measured for 5 x 10(-5)M protein in both the absence and presence of 10(-2)M sodium dodecyl sulfate (SDS). In the course of these experiments, 370 quantitative protein deamidation measurements were performed and 37 deamidation rates were determined ...
Noah E, Robinson +4 more
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Human molecular genetics, 2006
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar aggregates of alpha-synuclein in characteristic inclusions known as "Lewy bodies". As mutations altering alpha-synuclein structure or increasing alpha-synuclein expression level can cause familial forms of PD or related Lewy body disorders, alpha-synuclein is believed ...
Yuxin, Fan +7 more
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Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar aggregates of alpha-synuclein in characteristic inclusions known as "Lewy bodies". As mutations altering alpha-synuclein structure or increasing alpha-synuclein expression level can cause familial forms of PD or related Lewy body disorders, alpha-synuclein is believed ...
Yuxin, Fan +7 more
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An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology
Neuron, 2023Erik S Musiek
exaly
2009
Parkinson disease is an age-related disorder. It was seen all part of society. It is existed by genetic predisposition and different effects. The disease usually starts insidously and its symptoms progress slow but causing acceleration. Middle brain gets narrow according to normal brain in Parkinson, pigmentation is decreased in substantia nigra pars ...
Başaran, A., Bayram, B., Ak, A.
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Parkinson disease is an age-related disorder. It was seen all part of society. It is existed by genetic predisposition and different effects. The disease usually starts insidously and its symptoms progress slow but causing acceleration. Middle brain gets narrow according to normal brain in Parkinson, pigmentation is decreased in substantia nigra pars ...
Başaran, A., Bayram, B., Ak, A.
openaire +1 more source
Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns
Brain, 2022Shady Rahayel +2 more
exaly
Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats
Brain, 2021Nathalie Van Den Berge +2 more
exaly