Results 241 to 250 of about 68,100 (329)

Clinical Trial Highlights: Targeting Alpha-Synuclein

Journal of Parkinson's Disease, 2019
Kevin, McFarthing, Tanya, Simuni
openaire   +3 more sources

Coupling CZE, Liquid‐Phase Ion Mobility, to MS/MS for Quantitative Top‐Down Proteomics: Revealing Significant Proteoform Differences Between Healthy and Alzheimer's Disease Brains

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression.
Mehrdad Falamarzi Askarani, Fei Fang, Scott E. Counts, Liangliang Sun   +3 more
wiley   +1 more source

Expression of human A53T alpha-synuclein without endogenous rat alpha-synuclein fails to elicit Parkinson's disease-related phenotypes in a novel humanized rat model. [PDF]

PLoS One
Polinski NK, Puoliväli J, Rauhala L, Stenius TK, Bragge T, Parkkari T, Penttinen AM, Chen Y, Mabrouk OS, Glajch KE, Hirst WD, Perkinton M, Martinez TN, Frasier MA.   +13 more
europepmc   +1 more source

Probing Early α‐Synuclein Oligomers: Insights Into Aggregation Pathways of NACore and preNAC Segments Probed by Trapped Ion‐Mobility Mass Spectrometry and Fluorescence Spectroscopy

PROTEOMICS, EarlyView.
ABSTRACT Misfolding and aggregation of α‐Synuclein (α‐Syn) play a central role in Parkinson's disease (PD), with oligomeric intermediates implicated as key toxic species. Here, we investigate the aggregation of two α‐Syn segments, the NACore (68GAVVTGVTAVA78, WT‐PD1) and the preNAC region (47GVVHGVATVA56, WT‐PD2), using high‐resolution trapped ion ...
Agathe Depraz Depland, Stephanie Mikromanolis, Iuliia Stroganova, Anouk M. Rijs   +3 more
wiley   +1 more source

Alpha-synuclein overexpression does not cause vocalization deficits in a mouse model of parkinsonism. [PDF]

Biol Open
Rodgers B, Schaser A.
europepmc   +1 more source

Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms

Laura Bellingacci, Miriam Sciaccaluga, Alfredo Megaro, Antonella Cardinale, Jacopo Canonichesi, Maria De Carluccio, Roberta Mastrantonio, Cinzia Costa, Massimiliano Di Filippo, Alessandro Usiello, Maria Teresa Viscomi, Paolo Calabresi, Alessandro Tozzi   +12 more
openalex   +1 more source

Ow949 Zgis125[P(Dat-1)::Alpha-Synuclein::Yfp] | 2014-02-25T10:31:50+01:00

, 2018
Céline N. Martineau, Ellen A. A. Nollen
openalex   +1 more source

Associations of Vestibular Disorders With Risk of All‐Cause and Cause‐Specific Dementia: A Longitudinal Cohort Study in UK Biobank

Sensory Neuroscience, EarlyView.
ABSTRACT To explore associations of vestibular disorders with all‐cause and cause‐specific dementia and underlying biological mechanisms/neuroimaging changes. A population‐based cohort study of 406,348 UK Biobank participants was conducted. Inverse probability of treatment weighting (IPTW) balanced baseline covariates, and Cox proportional hazards ...
Xiaofei Li, Fan Jiang, Qiuyue Dong, Hao Chen, Hanbing Ji, Alimu Dayimu, Yifan Yu, Guorong Li, Na Li, Peipei Fu, Qi Jing, Maoli Duan, Hongkai Li, Shanquan Chen, Daogong Zhang, Haibo Wang   +15 more
wiley   +1 more source

New Hybrid Nanocomposite Films for Optical Diagnostics and Optical Temperature Sensing: Synergy Among α‐Synuclein, Gold and Upconverting Nanoparticles

Small, EarlyView.
Gold and upconverting nanoparticles coated with alpha‐synuclein were exploited to produce a quasi‐monolayer hybrid film. The film was then characterized, and its behaviour as a primary optical nano‐thermometer was studied. The film was also used in a proof‐of‐concept study of image‐based optical nanothermometry exploiting a home‐built up‐conversion ...
Emil Milan, Roberto Tira, Chiara Cressoni, Federico Antonio Giacomazzi, Patrizia Canton, Michael Assfalg, Adolfo Speghini   +6 more
wiley   +1 more source