Results 251 to 260 of about 1,144,970 (369)

Comparison of Two α‐Synuclein Seed Amplification Assays for Discrimination of Parkinson Disease and Atypical Parkinsonism

Movement Disorders, EarlyView.
Abstract Background Seed amplification assays (SAAs) for misfolded α‐synuclein (syn) have shown inconsistent results in multiple system atrophy (MSA). Objective The objective of this study was to compare a novel syn SAA (synSAA) that distinguishes between Lewy body disease (LBD) and MSA syn‐seeds (Amprion‐SAA) with an LBD‐specific synSAA (IRCCS ...
Marcello Rossi, Carly M. Farris, Simone Baiardi, Giulia Giannini, Franco Magliocchetti, Luisa Sambati, Yihua Ma, Erica Vittoriosi, Giovanna Calandra‐Buonaura, Luis Concha‐Marambio, Piero Parchi   +10 more
wiley   +1 more source

Imaging alpha-synuclein pathology in Parkinson's disease. [PDF]

Neural Regen Res
Ni R.
europepmc   +1 more source

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.

, 2000
Declan Murphy, Susan M. Rueter, John Q. Trojanowski, Virginia M.‐Y. Lee   +3 more
openalex  

Lighting Up Alpha-synuclein Oligomers [PDF]

EBioMedicine, 2018
openaire   +4 more sources

Distinct AQP4 Alterations in Movement Disorders with Primary Synucleinopathy

Movement Disorders, EarlyView.
Abstract Background Aquaporin‐4 (AQP4) is involved in clearing amyloidogenic proteins, but it remains unexplored how it is comparatively altered in neuron‐ and oligodendrocyte‐predominant synucleinopathies. Objective The aim was to assess AQP4 protein localization and abundance in Parkinson's disease (PD) and multiple system atrophy (MSA).
Lingbing Wang, Onur Tanglay, Feifei Su, Hongyun Li, Jun Liu, Woojin S. Kim, Glenda M. Halliday, YuHong Fu   +7 more
wiley   +1 more source

Identification of small molecule dimethyoxyphenyl piperazine inhibitors of alpha-synuclein fibril growth. [PDF]

Sci Rep
Hwang H, Dhavale DD, Wang SJ, Guduputi A, Beale JM, Cairns NJ, Kotzbauer PT.   +6 more
europepmc   +1 more source

Over‐expression of alpha‐synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain [PDF]

, 2010
Heike Siebert, Philipp J. Kahle, M. Kramer, Thomas Isik, Oliver M. Schlüter, Walter Schulz‐Schaeffer, Wolfgang Brück   +6 more
openalex   +1 more source

Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies

Movement Disorders, EarlyView.
Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Lachlan Churchill, Anna Ignatavicius, Ajay Konuri, Jack Anderson, Natasha Taylor, Simon J.G. Lewis, Elie Matar   +6 more
wiley   +1 more source

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes. [PDF]

Acta Neuropathol
Wihan J, Battis K, Hoffmann A, Windener F, Himmler M, Varghese A, Koller A, Karnatz I, Schubert DW, Zunke F, Xiang W, Kuhlmann T, Winkler J.   +12 more
europepmc   +1 more source

Alpha-Synuclein is localized in a subpopulation of rat brain synaptic vesicles

, 2008
Seung‐Jae Lee, Hyesung Jeon, Konstantin V. Kandror   +2 more
openalex   +2 more sources