Results 261 to 270 of about 68,100 (329)

Ow949 Zgis125[P(Dat-1)::Alpha-Synuclein::Yfp] | 2014-03-04T09:27:46+01:00

, 2018
Céline N. Martineau, Ellen A. A. Nollen
openalex   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Alpha-synuclein fibrils induce budding of mitochondrial-derived vesicles

Braun T, Tiberi C, Reber V, Ghosh D, Riek R, Serdiuk T.   +5 more
europepmc   +1 more source

Ow949 Zgis125[P(Dat-1)::Alpha-Synuclein::Yfp] | 2014-03-13T14:45:28+01:00

, 2018
Céline N. Martineau, Ellen A. A. Nollen
openalex   +1 more source

14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders

Brain Pathology, EarlyView.
14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García, Jorge Mena, Carol‐Ann Lao, David Adamuz, Laura Arnaldo, Cristina Carrato, Alex Menendez, Daniela Samaniego, Dolores Vilas, Lourdes Ispierto, Anna Planas, Ramiro Alvarez, Pau Pastor, Katrin Beyer   +13 more
wiley   +1 more source

Alpha-Synuclein Neurobiology in Parkinson's Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives. [PDF]

Brain Sci
Pitton Rissardo J, McGarry A, Shi Y, Fornari Caprara AL, Kannarkat GT.   +4 more
europepmc   +1 more source

Ow940 Zgis128[P(Dat-1)::Alpha-Synuclein::Yfp] | 2014-04-05T14:33:26+02:00

, 2018
Céline N. Martineau, Ellen A. A. Nollen
openalex   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Determinants of alpha-synuclein pathogenesis in Parkinson's disease. [PDF]

Neural Regen Res
Bárcenas O, Estivill-Alonso M, Ventura S.   +2 more
europepmc   +1 more source