Results 261 to 270 of about 1,144,970 (369)

Drug Targets from Genetics: Alpha-Synuclein [PDF]

, 2011
Karin M. Danzer, Pamela J. McLean
openalex   +1 more source

Reply: “PGRN Manifesting as Parkinson's Disease: Counseling and Treatment Implications”

Movement Disorders Clinical Practice, EarlyView.
Angelo Antonini, Giulia Bonato, Miryam Carecchio   +2 more
wiley   +1 more source

Allogeneic Bone Marrow‐Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial

Movement Disorders, EarlyView.
Abstract Background Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo‐hMSCs) may reduce neuroinflammation and improve motor symptoms. Objectives To evaluate the efficacy of repeated intravenous doses of 10 × 106/kg allo‐hMSCs in improving motor symptoms in patients
Mya C. Schiess, Jessika Suescun, Juan D. Martinez‐Lemus, Charles Green, Tia S. Thomas, Mohammad Shahnawaz, Emily Tharp, Nikunj B. Satani, Jerome G. Saltarrelli, Christopher Adams, Marie‐Francoise Doursout, Vanessa Thyne, Rula Abuamouneh, Elsa M. Rodarte, Sean I. Savitz, Timothy M. Ellmore   +15 more
wiley   +1 more source

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features. [PDF]

Mol Neurodegener
Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, Lautenschläger J, Zweckstetter M, Busnadiego RF, Zimprich A, Outeiro TF.   +19 more
europepmc   +1 more source

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

, 2002
Deniz Kirik, Carl Rosenblad, Corinna Bürger, Cecilia Lundberg, Teit E. Johansen, Nicholas Muzyczka, Ronald J. Mandel, Anders Björklund   +7 more
openalex  

P2‐372: Development of oligomer‐specific alpha‐synuclein antibodies

, 2008
Therese Wahlberg, Tomas Näsström, Marie Hedlund, Frida Ekholm Pettersson, Lars Lannfelt, Martin Ingelsson, Joakim Bergström   +6 more
openalex   +1 more source

Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression [PDF]

, 2011
Jesse R. McLean, Penelope J. Hallett, Oliver Cooper, Michael Stanley, Ole Isacson   +4 more
openalex   +1 more source

Patient‐Derived Neurons Exhibit α‐Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein–Associated Neurodegeneration

Movement Disorders, EarlyView.
Abstract Background Mitochondrial membrane protein–associated neurodegeneration (MPAN) from the neurodegeneration with brain iron accumulation (NBIA) family is a rare neurodegenerative disease marked by α‐synuclein aggregation, brain iron accumulation, and midbrain dopaminergic neuron degeneration.
Leonie M. Heger, Leonie Kertess, Clara Kaufhold, Francesco Gubinelli, Aida Cardona‐Alberich, Gamze Özata, Stephan A. Müller, Sarah K. Tschirner, Oliver Stehling, Martina Schifferer, Camille Peron, Valeria Tiranti, Roland Lill, Arcangela Iuso, Luigi Zecca, Michael Strupp, Wolfgang Oertel, Stefan F. Lichtenthaler, Lena F. Burbulla   +18 more
wiley   +1 more source

Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons [PDF]

, 2011
Yofre Cabeza-Arvelaiz, Sheila M. Fleming, Franziska Richter, Eliezer Masliah, Marie‐Françoise Chesselet, Robert H. Schiestl   +5 more
openalex   +1 more source

A Novel α‐Synuclein K58N Missense Variant in a Patient with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α‐synuclein (aSyn), are linked to rare familial forms of PD. Objective Our goal was to assess the clinical presentation and the biological effects of a novel K58N ...
Mohammed Al‐Azzani, Sandrina Weber, Nagendran Ramalingam, Maria Ramón, Liana Shvachiy, Gonçalo Mestre, Michael Zech, Kevin Sicking, Alain Ibáñez de Opakua, Vidyashree Jayanthi, Leslie Amaral, Aishwarya Agarwal, Aswathy Chandran, Susana R. Chaves, Juliane Winkelmann, Claudia Trenkwalder, Maike Schwager, Silke Pauli, Ulf Dettmer, Claudio O. Fernández, Janin Lautenschläger, Markus Zweckstetter, Ruben Fernandez‐Busnadiego, Brit Mollenhauer, Tiago Fleming Outeiro   +24 more
wiley   +1 more source