Results 61 to 70 of about 1,144,970 (369)
Scientific Reports, 2023 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need.
Danuta Sastre +7 more
doaj +1 more source
Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk
Frontiers in Cellular Neuroscience, 2021 Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson’s disease (PD). Despite its toxic properties during PD, alpha-synuclein has some important physiological functions.
Alix Booms, Gerhard A. Coetzee
doaj +1 more source
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
Nature Communications, 2020 Parkinson’s disease and related synucleinopathies are characterized by the abnormal accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the substantia nigra.
I. Pediaditakis +11 more
semanticscholar +1 more source
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]
, 2017 Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T +9 more
core +1 more source
Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles
Frontiers in Neuroscience, 2020 Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its physiological functions are only partially understood. α-syn accumulation is associated with Parkinson’s disease, dementia with Lewy bodies, and multiple system ...
L. D. Bernal-Conde +7 more
semanticscholar +1 more source
Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. [PDF]
, 2009 Alpha-synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is ...
Bernard, David J +10 more
core +2 more sources
Free Neuropathology, 2020 Deposition of alpha-synuclein in the brain is a hallmark of Lewy body disorders. Alpha-synuclein has been considered to show prion-like properties.
Ellen Gelpi +7 more
doaj +1 more source
Alpha-synuclein oligomers: a new hope [PDF]
Acta Neuropathologica, 2017 Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the main pathological drivers in the disease, although it remains unclear how this protein elicits its neurotoxic effects. Recent findings indicate that the assembly of toxic oligomeric species of alpha-synuclein may be one of the key processes for the pathology and
Nora Bengoa-Vergniory +3 more
openaire +4 more sources
Dopamine-induced conformational changes in alpha-synuclein. [PDF]
PLoS ONE, 2009 Oligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using ...
Tiago F Outeiro +8 more
doaj +1 more source
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
Nature Communications, 2020 As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large conformational space. Certain conformations lead to aggregation prone and non-aggregation prone intermediates, but identifying these within the dynamic ensemble of ...
Amberley D. Stephens +12 more
semanticscholar +1 more source