Association between Serum Alpha-Synuclein Levels and Parkinson's Disease Stage
Global Medical & Health Communication, 2022 Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's. It is chronically progressive with the main symptoms of resting tremor, rigidity, bradykinesia, and postural disturbances.
Yuliarni Syafrita, Restu Susanti
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Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. [PDF]
, 2014 BackgroundIn dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum.
Cartier, Anna +9 more
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Parkinson's disease (PD) is the most common neurodegenerative disease
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015 Metabolic impairment of alpha-synuclein protein is considered to be the central event in PDpathogenesis. Recent studies explored usage of alpha-synuclein in peripheral fluids as a biomarker of PD, however alpha-synuclein level in the CSF and plasma is ...
P. A. Andoskin +7 more
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Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications [PDF]
, 2019 Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes ...
Alza, Natalia Paola +4 more
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Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults
Annals of Clinical and Translational Neurology, 2020 Objective Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha‐synuclein in the brain, which was indicated by alpha‐synuclein levels in
Xiao‐Tong Wang +7 more
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Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson\xe2\x80\x99s disease [PDF]
, 2018 The involvement of DNA damage and repair in aging processes is well established. Aging is an unequivocal risk factor for chronic neurodegenerative diseases, underscoring the relevance of investigations into the role that DNA alterations may have in the ...
Blandini, F. (Fabio) +9 more
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Alpha-Synuclein Is a Cellular Ferrireductase [PDF]
PLoS ONE, 2011 α-synuclein (αS) is a cellular protein mostly known for the association of its aggregated forms with a variety of diseases that include Parkinson's disease and Dementia with Lewy Bodies. While the role of αS in disease is well documented there is currently no agreement on the physiological function of the normal isoform of the protein.
Davies, Paul +2 more
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Plasma and Serum Alpha-Synuclein as a Biomarker of Diagnosis in Patients With Parkinson's Disease
Frontiers in Neurology, 2020 Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, and α-synuclein plays a critical role in the pathogenesis of PD.
Chun-Wei Chang +4 more
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Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells
Molecular Neurobiology, 2021 Parkinson’s disease is a progressive neurodegenerative disorder characterized by the accumulation of misfolded alpha-synuclein in intraneuronal inclusions known as Lewy bodies and Lewy neurites.
Eftychia Vasili +7 more
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Astrocytes and Alpha-Synuclein: Friend or Foe?
Journal of Parkinson’s Disease, 2023 Despite its devastating disease burden and alarming prevalence, the etiology of Parkinson’s disease (PD) remains to be completely elucidated. PD is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta and this correlates with the accumulation of misfolded α-synuclein.
Ozoran, H, Srinivasan, R
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