Results 141 to 150 of about 5,528 (200)

Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases. [PDF]

ACS Med Chem Lett
Abdel-Magid AF.
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Nicotine Regulates LPS-Induced Inflammatory Responses in HMC3 Microglia and Exerts Neuronal Protection. [PDF]

Mediators Inflamm
Qin Y, Yan X, Luo Y, Wang H, Tian Y, Wu X, Chen H, Hou H, Hu Q.   +8 more
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Bridging cholinergic signalling and inflammation in schizophrenia. [PDF]

Schizophrenia (Heidelb)
Metz CN, Brines M, Pavlov VA.
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Antifibrotic Effects of an α7 Nicotinic Acetylcholine Receptor Agonist in Keloid Fibroblasts and a Rat Scar Model. [PDF]

Int J Mol Sci
Roh H, Kim YH, Heo KJ, Hong JW, Lee WJ.
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Liraglutide modulates cyclooxygenase and α7 acetylcholine receptors: in vitro and in silico insights into its anti-inflammatory role in LPS-induced inflammation in RAW 264.7 macrophages. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Baris E, Portakal HS, Aslan A, Firtina Karagonlar Z, Tosun M.   +4 more
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Peripheral Parasympathetic Networks in Pain: A Systems-Level Review of Mechanisms and Modulations. [PDF]

Cell Mol Neurobiol
Yang R, Jia S, Li Y, Yang H, Han Z, Liang L, Huang F, Fan W.   +7 more
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α7 nicotinic acetylcholine receptor agonist attenuates lipopolysaccharide-induced acute kidney injury in mice by reducing CCL2 expression in macrophages. [PDF]

Sci Rep
Matsuo S, Uni R, Wu CH, Nakamura Y, Umene R, Surattichaiyakul B, Nangaku M, Inagi R, Nishino T, Inoue T.   +9 more
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Targeting Alpha7 Nicotinic Acetylcholine Receptors in Lung Cancer: Insights, Challenges, and Therapeutic Strategies. [PDF]

ACS Pharmacol Transl Sci
Arunrungvichian K, Vajragupta O, Hayakawa Y, Pongrakhananon V.   +3 more
europepmc   +1 more source

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Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia

Expert Opinion on Therapeutic Targets, 2012
Schizophrenia is a profoundly debilitating disease that represents not only an individual, but a societal problem. Once characterized solely by the hyperactivity of the dopaminergic system, therapies directed to dampen dopaminergic neurotransmission were developed.
Tanya L, Wallace, Daniel, Bertrand
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Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

Biochemical Pharmacology, 2011
A promising drug target currently under investigation to improve cognitive deficits in neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine receptor (α7nAChR). Improving cognitive impairments in diseases such as Alzheimer's (AD) and schizophrenia remains a large unmet medical need, and the α7nAChR has many ...
Tanya L, Wallace, Richard H P, Porter
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