Results 151 to 160 of about 5,528 (200)
Toxics, 2020 Current cigarette smoking is associated with chronic kidney disease (CKD) or death from end-stage renal disease (ESRD). Mainstream cigarette smoke includes over 4000 compounds.
Cai-Mei Zheng +2 more
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Medical Hypotheses, 2012
The long prevailing hypothesis of schizophrenia pathogenesis implicates dopaminergic systems in the mesolimbic pathways as responsible for the positive symptoms of schizophrenia (hallucinations and delusions) and those in the mesocortical pathway as contributing to the negative symptoms (e.g., social disconnection, flattened affect and anhedonia ...
Merouane, Bencherif +3 more
openaire +3 more sources
The long prevailing hypothesis of schizophrenia pathogenesis implicates dopaminergic systems in the mesolimbic pathways as responsible for the positive symptoms of schizophrenia (hallucinations and delusions) and those in the mesocortical pathway as contributing to the negative symptoms (e.g., social disconnection, flattened affect and anhedonia ...
Merouane, Bencherif +3 more
openaire +3 more sources
The alpha7 integrin subunit in astrocytes promotes endothelial blood-brain barrier integrity.
Development, 2023The blood-brain barrier (BBB) is a vascular endothelial cell boundary that partitions the circulation from the central nervous system to promote normal brain health.
Zhihua Chen +6 more
semanticscholar +1 more source
Planta Medica, 2021
Berberine is an isoquinoline derivative alkaloid extracted from Chinese herbs. Recent studies have demonstrated the therapeutic effect of berberine on glucose metabolic disorders. However, its specific mechanism is still unclear.
Ding-kun Wang +8 more
semanticscholar +1 more source
Berberine is an isoquinoline derivative alkaloid extracted from Chinese herbs. Recent studies have demonstrated the therapeutic effect of berberine on glucose metabolic disorders. However, its specific mechanism is still unclear.
Ding-kun Wang +8 more
semanticscholar +1 more source
Alpha7 nicotinic acetylcholine receptors in lung inflammation and carcinogenesis: Friends or foes?
Journal of Cellular Physiology, 2019The lung tissue expresses the cholinergic system including nicotinic acetylcholine receptors (nAChRs) which included in many physiologic and pathologic processes. Mounting evidence revealed that these receptors have important roles in lung carcinogenesis
Khalil Hajiasgharzadeh +2 more
exaly +2 more sources
Frontiers in Immunology, 2017 Alpha7 nicotinic acetylcholine receptor (α7nAChR) has been reported to alleviate neuroinflammation. Here, we aimed to determine the role of autophagy in α7nAChR-mediated inhibition of neuroinflammation and its underlying mechanism.
Ping Ke, Xiongwen Chen, Ding-Feng Su
exaly +2 more sources
Alpha7 nicotinic‐N‐methyl‐D‐aspartate hypothesis in the treatment of schizophrenia and beyond
Human psychopharmacology, 2020Development of novel treatments for positive, cognitive, and negative symptoms continue to be a high‐priority area of schizophrenia research and a major unmet clinical need. Given that all randomized controlled trials (RCTs) conducted to date failed with
M. Koola
semanticscholar +1 more source
alpha7 receptor-selective agonists and modes of alpha7 receptor activation.
European journal of pharmacology, 2000The alpha7-selective agonists 3-(2, 4-dimethoxybenzylidene)-anabaseine (GTS-21), also known as DMXB, and 3-(4-hydroxy,2-methoxybenzylidene)anabaseine (4OH-GTS-21) produce a variety of behavioral and cytoprotective effects that may be related to the activation of either large transient currents at high concentrations or small sustained currents at lower
R L, Papke +3 more
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Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection
Biochemical Pharmacology, 2015Javier Egea, Elisa Navarro, Rafael León
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