Results 161 to 170 of about 5,528 (200)
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Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000Nicotinic acetylcholine receptors in the nervous system are heterogeneous with distinct pharmacological and functional properties resulting from differences in post-translational processing and subunit composition. Because of nicotinic receptor diversity, receptor purification and biochemical characterization have been difficult, and the precise ...
R C, Drisdel, W N, Green
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Medical Oncology, 2022
Hepatocellular carcinoma (HCC), the most prevalent kind of liver cancer, remains one of the world's main causes of death. The alpha7 nicotinic acetylcholine receptor (α7nAchR) has been recognized to be overexpressed in malignancies and chemoresistance.
Mina Afrashteh Nour +3 more
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Hepatocellular carcinoma (HCC), the most prevalent kind of liver cancer, remains one of the world's main causes of death. The alpha7 nicotinic acetylcholine receptor (α7nAchR) has been recognized to be overexpressed in malignancies and chemoresistance.
Mina Afrashteh Nour +3 more
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Protective effect of alpha7 nAChR: Behavioural and morphological features on neuropathy
Pain, 2010Traumatic, toxic or metabolic damage to the nervous system is the etiological foundation of neuropathic pain. Neuropathies are extremely difficult to treat and available drugs rarely joint an anti-hyperalgesic with a neurorestorative effect. From the literature, evidences support the alpha7 nicotinic receptor (nAChR) subtype as having a role in ...
PACINI, ALESSANDRA +5 more
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Proceedings of the National Academy of Sciences of the United States of America, 1997
Injection of cDNA encoding the neuronal alpha7 subunit into Xenopus oocytes yields homomeric receptors showing responses to AcCho that have low affinity, fast desensitization, nonlinear current-voltage (I-V) relation, and sensitivity to alpha-bungarotoxin (alpha-BTX) and 5-hydroxytryptamine (5HT), both substances acting as antagonists.
PALMA, Eleonora +2 more
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Injection of cDNA encoding the neuronal alpha7 subunit into Xenopus oocytes yields homomeric receptors showing responses to AcCho that have low affinity, fast desensitization, nonlinear current-voltage (I-V) relation, and sensitivity to alpha-bungarotoxin (alpha-BTX) and 5-hydroxytryptamine (5HT), both substances acting as antagonists.
PALMA, Eleonora +2 more
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Alpha7 Neuronal Nicotinic Receptor: A Pluripotent Target for Diseases of the Central Nervous System
CNS and Neurological Disorders - Drug Targets, 2014M. Bencherif, S. Narla, M. Stachowiak
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Neuroscience, 2013 Selective alpha7 nicotinic acetylcholine receptor ligands.
Current medicinal chemistry, 2006Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand gated ion channels of broad distribution and structural heterogeneity. Their functional diversity demonstrated involvement in a variety of neuronal processes (e.g., sensory gating and cognitive function) and generated great interest in them as targets for therapeutic intervention in a ...
Anatoly, Mazurov +2 more
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The antitussive effects of alpha7 (α7) nicotinic receptor agonists
Airway Pharmacology and Treatment, 2017Background: Agonists for subtypes of the nicotinic class of acetylcholine receptors (nAChRs) have been evaluated for therapeutic effects in CNS disorders, pain and inflammation. A recent study in healthy nonsmokers described a marked antitussive effect of nicotine-containing vapors produced by e-Cigarettes (Chest 2016;149:161-5), a result consistent ...
Peter Dicpinigaitis +6 more
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Alpha7 nicotinic acetylcholine receptor activation attenuated intestine-derived acute lung injury
Journal of Surgical Research, 2016Intestinal ischemia-reperfusion (IIR) could lead to acute lung injury, associated with severe alveolar epithelial cells inflammatory and oxidative injury. Alpha7 nicotinic acetylcholine receptor (α7nAChR) is an essential component of the cholinergic anti-inflammatory pathway. The aim of this study was to investigate the important role of α7nAChR on the
Ye, He +6 more
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Alpha7 cholinergic-agonist prevents systemic inflammation by Sepsis. (179.3)
The Journal of Immunology, 2012Abstract The alpha7 nicotinic acetylcholine receptors (α7nAChR) play a critical role in modulating systemic inflammation in sepsis (1). However, α7nAChR-agonists have failed to provide significant advantages in several pilot studies with septic patients.
Maria del Thompson-Bonilla +3 more
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