Results 171 to 180 of about 5,528 (200)

Alpha7 neuronal nicotinic receptors: The missing link to understanding Alzheimer’s etiopathology?

Medical Hypotheses, 2010
Evidence supports the premise that alpha7 nicotinic acetylcholine receptors in the central nervous system, sometimes referred to as neuronal nicotinic receptors (NNRs), play a central role in the development of Alzheimer's disease (AD) pathophysiology. Moreover, these receptors may represent the key to unifying aspects of the cholinergic hypothesis of ...
Merouane, Bencherif, Patrick M, Lippiello   +1 more
openaire   +2 more sources

Chemotherapy-induced neuropathy: involvement of the alpha7 nAChR subtype

2011
The limiting side effect of the chemotherapeutic agent oxaliplatin is its neurotoxicity, which promotes a neuropathic syndrome. In a rat model of oxaliplatin-induced neuropathy (2.4 mgkg-1 intraperitoneally, daily injected for 21 days), a dramatic decrease of the alpha7 nAChR protein expression levels was highlighted in the peripheral as well as ...
L. Di Cesare Mannelli, C. Dallanoce, C. Matera, M. Zanardelli, A. Pacini, C. De Micheli, M. De Amici, C. Ghelardini   +7 more
openaire   +2 more sources

Impaired axonal regeneration in alpha7 integrin-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
The interplay between growing axons and the extracellular substrate is pivotal for directing axonal outgrowth during development and regeneration. Here we show an important role for the neuronal cell adhesion molecule alpha7beta1 integrin during peripheral nerve regeneration.
A, Werner, M, Willem, L L, Jones, G W, Kreutzberg, U, Mayer, G, Raivich   +5 more
openaire   +1 more source

Picrotoxin-mediated antagonism of alpha3beta4 and alpha7 acetylcholine receptors.

Neuroreport, 2004
Picrotoxin (PTX) is a convulsant that antagonizes many inhibitory ligand-gated receptors. The mechanism of PTX block is believed to involve residues which line the pore in the second transmembrane domain (M2). The alpha(3)beta(4) and alpha(7) nicotinic acetylcholine receptors (nAChRs) have high homology to inhibitory LGICs in this M2 region and ...
Brian E, Erkkila, David S, Weiss, Virginia E, Wotring   +2 more
openaire   +1 more source

Small Molecules as Negative Allosteric Modulators of Alpha7 nAChRs

2012
VCU Theses and ...
openaire   +1 more source

Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory.

Brain research, 2006
Nicotinic receptor systems have been shown to be important for working memory. In general, nicotinic agonists have been shown to improve memory, and nicotinic antagonists impair it. All of the neuronal substrates for nicotinic involvement in memory still remain to be discovered.
Alexi, Nott, Edward D, Levin
openaire   +1 more source

S.20.02 Alpha7 nicotinic receptors and synaptic plasticity

European Neuropsychopharmacology, 2010
H.D. Mansvelder, R.B. Poorthuis, B. Bloem, K. Guillem   +3 more
openaire   +1 more source

First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288

Journal of Psychopharmacology, 2017
K. Gee, A. Olincy, R. Kanner, L. Johnson, D. Hogenkamp, Josette G. Harris, M. Tran, Stephen A Edmonds, William J Sauer, R. Yoshimura, T. Johnstone, R. Freedman   +11 more
semanticscholar   +1 more source

Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction.

Biochemical Pharmacology, 2015
Elisa Navarro, Izaskun Buendía, Esther Parada, R. León, P. Jansen-Duerr, Haymo Pircher, J. Egea, Manuela G. López   +7 more
semanticscholar   +1 more source

Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats

Psychopharmacology, 2014
Kelli M. Jones, I. Mcdonald, C. Bourin, R. Olson, L. Bristow, Amy E. Easton   +5 more
semanticscholar   +1 more source