Results 161 to 170 of about 2,877 (196)

Putative α7-selective ligands interact with α9-containing nicotinic acetylcholine receptors and modulate immune functions of human mononuclear phagocytes. [PDF]

Front Immunol
Mobasher M, Hone AJ, Pilzecker M, Bozic D, Hecker A, McIntosh JM, Kirschner KN, Grau V, Papke RL, Andleeb H, Richter K.   +10 more
europepmc   +1 more source

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Alpha7 nicotinic acetylcholine receptors in lung inflammation and carcinogenesis: Friends or foes?

Journal of Cellular Physiology, 2019
AbstractThe lung tissue expresses the cholinergic system including nicotinic acetylcholine receptors (nAChRs) which included in many physiologic and pathologic processes. Mounting evidence revealed that these receptors have important roles in lung carcinogenesis via modulating either stimulatory or inhibitory signaling pathways. Among different members
Khalil Hajiasgharzadeh, Saeed Sadigh-Eteghad, Behzad Mansoori   +2 more
exaly   +3 more sources

Crosstalk between tau and alpha7 nicotinic acetylcholine receptors at the synapse

Alzheimer's & Dementia, 2023
AbstractBackgroundThe failure of cholinergic transmission and the increase of amyloid‐β peptide (Aβ) and tau protein are key players in Alzheimer’s disease (AD). The interaction between α7 nicotinic acetylcholine receptors (α7‐nAChRs) and Aβ has been previously investigated, but few studies have focused on the crosstalk between α7‐nAChRs and tau.
Maria Rosaria Tropea, Domenica Donatella Li Puma, Marcello Melone, Walter Gulisano, Valeria Vacanti, Ottavio Arancio, Claudio Grassi, Fiorenzo Conti, Daniela Puzzo   +8 more
openaire   +1 more source

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

Biochemical Pharmacology, 2011
A promising drug target currently under investigation to improve cognitive deficits in neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine receptor (α7nAChR). Improving cognitive impairments in diseases such as Alzheimer's (AD) and schizophrenia remains a large unmet medical need, and the α7nAChR has many ...
Tanya L, Wallace, Richard H P, Porter
openaire   +2 more sources

Aryloxyethylamines: Binding at α7 nicotinic acetylcholine receptors

Bioorganic & Medicinal Chemistry Letters, 2006
Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha7 nACh receptors were investigated due to its close structural similarity to a known alpha7 antagonist.
Hanan M, Ragab, Jin Sung, Kim, Małgorzata, Dukat, Hernán, Navarro, Richard A, Glennon   +4 more
openaire   +2 more sources

Schizophrenia and the α7 Nicotinic Acetylcholine Receptor

2007
In addition to the devastating symptoms of psychosis, many people with schizophrenia also suffer from cognitive impairment. These cognitive symptoms lead to marked dysfunction and can impact employability, treatment adherence, and social skills. Deficits in P50 auditory gating are associated with attentional impairment and may contribute to cognitive ...
Laura F, Martin, Robert, Freedman
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The α7 nicotinic acetylcholine receptor in neuronal plasticity

Molecular Neurobiology, 1999
A growing body of evidence indicates that neuronal nicotinic acetylcholine receptors (nAChRs), in addition to promoting fast cholinergic transmission, may modulate other neuronal activities within the central nervous system (CNS). In particular, the alpha7 nAChR is highly permeable to Ca2+ and may serve a distinct role in regulating neuronal plasticity.
R S, Broide, F M, Leslie
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Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit

2014
Nicotinic acetylcholine receptors (nAChR) are members of the Cys-loop superfamily of ligand-gated ion channels that includes glycine, γ-aminobutyric acid (GABAA), and serotonin receptor channels. The members of the family are defined by a similar pentameric structure with five membrane-spanning subunits surrounding a central water-filled, cation ...
Michael Paolini, Mariella De Biasi, John A. Dani   +2 more
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Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease

Journal of Molecular Graphics and Modelling, 2013
Alzheimer's disease (AD) is the most common form of dementia. Although its cause and mechanism of progression are not well understood, various in vitro and in vivo experiments have proved that the decreased activity of the cholinergic neuron is responsible for the memory damage that is observed in these patients.
Shi-Gao, Chen, Ruo-Xu, Gu, Hao, Dai, Dong-Qing, Wei   +3 more
openaire   +2 more sources

Application of Alpha7 Nicotinic Acetylcholine Receptor Agonists in Inflammatory Diseases: An Overview

Pharmaceutical Research, 2010
Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as ...
Mario B, Marrero, Merouane, Bencherif, Patrick M, Lippiello, Rudolf, Lucas   +3 more
openaire   +2 more sources