Results 151 to 160 of about 1,282,638 (192)
The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation [PDF]
British Journal of Pharmacology, 2007 The physiological regulation of the immune system encompasses comprehensive anti‐inflammatory mechanisms that can be harnessed for the treatment of infectious and inflammatory disorders. Recent studies indicate that the vagal nerve, involved in control of heart rate, hormone secretion and gastrointestinal motility, is also an immunomodulator.
Luis Ulloa, W J de Jonge
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Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration [PDF]
Neuroscience and Biobehavioral Reviews, 2008 Alzheimer's disease (AD) is the leading cause of dementia affecting over 25 million people worldwide. Classical studies focused on the description and characterization of the pathological hallmarks found in AD patients including the neurofibrillary tangles and the amyloid plaques.
Luis Ulloa +2 more
exaly +3 more sources
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Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease
Biochemical Pharmacology, 2011A promising drug target currently under investigation to improve cognitive deficits in neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine receptor (α7nAChR). Improving cognitive impairments in diseases such as Alzheimer's (AD) and schizophrenia remains a large unmet medical need, and the α7nAChR has many ...
Tanya L, Wallace, Richard H P, Porter
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Aryloxyethylamines: Binding at α7 nicotinic acetylcholine receptors
Bioorganic & Medicinal Chemistry Letters, 2006Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha7 nACh receptors were investigated due to its close structural similarity to a known alpha7 antagonist.
Hanan M, Ragab +4 more
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The α7 nicotinic acetylcholine receptor in neuronal plasticity
Molecular Neurobiology, 1999A growing body of evidence indicates that neuronal nicotinic acetylcholine receptors (nAChRs), in addition to promoting fast cholinergic transmission, may modulate other neuronal activities within the central nervous system (CNS). In particular, the alpha7 nAChR is highly permeable to Ca2+ and may serve a distinct role in regulating neuronal plasticity.
R S, Broide, F M, Leslie
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Crosstalk between tau and alpha7 nicotinic acetylcholine receptors at the synapse
Alzheimer's & Dementia, 2023AbstractBackgroundThe failure of cholinergic transmission and the increase of amyloid‐β peptide (Aβ) and tau protein are key players in Alzheimer’s disease (AD). The interaction between α7 nicotinic acetylcholine receptors (α7‐nAChRs) and Aβ has been previously investigated, but few studies have focused on the crosstalk between α7‐nAChRs and tau.
Maria Rosaria Tropea +8 more
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Schizophrenia and the α7 Nicotinic Acetylcholine Receptor
2007In addition to the devastating symptoms of psychosis, many people with schizophrenia also suffer from cognitive impairment. These cognitive symptoms lead to marked dysfunction and can impact employability, treatment adherence, and social skills. Deficits in P50 auditory gating are associated with attentional impairment and may contribute to cognitive ...
Laura F, Martin, Robert, Freedman
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Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit
2014Nicotinic acetylcholine receptors (nAChR) are members of the Cys-loop superfamily of ligand-gated ion channels that includes glycine, γ-aminobutyric acid (GABAA), and serotonin receptor channels. The members of the family are defined by a similar pentameric structure with five membrane-spanning subunits surrounding a central water-filled, cation ...
Michael Paolini +2 more
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Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease
Journal of Molecular Graphics and Modelling, 2013Alzheimer's disease (AD) is the most common form of dementia. Although its cause and mechanism of progression are not well understood, various in vitro and in vivo experiments have proved that the decreased activity of the cholinergic neuron is responsible for the memory damage that is observed in these patients.
Shi-Gao, Chen +3 more
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Pharmaceutical Research, 2010
Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as ...
Mario B, Marrero +3 more
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Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as ...
Mario B, Marrero +3 more
openaire +2 more sources