Results 131 to 140 of about 2,877 (196)

Fragmentation of NS6740 molecular skeleton to investigate the alpha7 nicotinic acetylcholine receptor silent activation

, 2018
NS6740 showed promising anti-inflammatory behavior by modulating alpha7 nicotinic acetylcholine receptors (1). The mechanism hypothesized is related to the ability of NS6740 to act as a “silent agonist”, stabilizing the desensitized states of the alpha7 ...
M. C. Pismataro, N. A. Horenstein, R. L. Papke, C. Dallanoce, C. Stokes   +4 more
core  

Novel simulation methods for characterizing conformational changes in nicotinic acetylcholine receptor analogues and beta-2-microglobulin

, 2012
Molecular simulation tools and protocols were developed for characterizing conformational changes in several proteins: beta2-microglobulin (beta2M), the nicotinic acetylcholine receptor (nAChR), the acetylcholine binding protein (AChBP), and an alpha7 ...
Stober, Spencer T.
core  

Serum Levels of Alpha7 Nicotinic Acetylcholine Receptor and Their Association With Cardiovascular Autonomic Function Tests in Healthy Young Adults. [PDF]

Cureus
Karthik S, Elakiya M, Balamurugesan K.
europepmc   +1 more source

Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane. [PDF]

Sci Rep, 2020
Moriwaki Y, Kubo N, Watanabe M, Asano S, Shinoda T, Sugino T, Ichikawa D, Tsuji S, Kato F, Misawa H.   +9 more
europepmc   +1 more source

Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders. [PDF]

Cell Mol Neurobiol
Abraham SM, Suresh S, Komal P.
europepmc   +1 more source

An alpha7 nicotinic acetylcholine receptor agonist induces retinal neurogenesis and restores electrophysiological function following blast-induced ocular trauma in adult mice. [PDF]

Front Neurosci
Nolasco de Carvalho GV, Spitsbergen JB, Linn DM, Linn CL.   +3 more
europepmc   +1 more source

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation. [PDF]

Eur J Med Chem, 2020
Pismataro MC, Horenstein NA, Stokes C, Quadri M, De Amici M, Papke RL, Dallanoce C.   +6 more
europepmc   +1 more source

Synergistic effects of memantine and alpha7 nicotinic acetylcholine receptor agonist PHA-543613 to improve memory of aged rats. [PDF]

Int J Neuropsychopharmacol
Bruszt N, Bali ZK, Nagy LV, Bodó K, Engelmann P, Hernádi I.   +5 more
europepmc   +1 more source

Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases. [PDF]

ACS Med Chem Lett
Abdel-Magid AF.
europepmc   +1 more source

Cellular Mechanisms of Cognitive Enhancement: The <i>In Vivo</i> Modulation of the Firing Activity and the Responsiveness of Rat Hippocampal Neurons by Memantine and Alpha7 Nicotinic Acetylcholine Receptor Ligands. [PDF]

ASN Neuro
Nagy LV, Bali ZK, Ledneczki I, Némethy Z, Lendvai B, Hernádi I.   +5 more
europepmc   +1 more source