Results 121 to 130 of about 2,877 (196)

Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics Poisson-Boltzmann surface area approach

, 2008
A group of agonists for the alpha7 neuronal nicotinic acetylcholine receptors (nAChRs) was investigated, and their free energies of binding DeltaG(bind) were calculated by applying the molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) approach.
De Micheli C., RECANATINI, MAURIZIO, De Amici M., CAVALLI, ANDREA, Grazioso G.   +4 more
core   +1 more source

The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia-reperfusion brain injury in mice. [PDF]

Biosci Rep, 2021
Hammarlund ME, Darsalia V, Mjörnstedt F, Pattanaik B, Mallard C, Rocha-Ferreira E, Patrone C, Johansson ME.   +7 more
europepmc   +1 more source

Dual Signaling Modes of Alpha7 Nicotinic Acetylcholine Receptors (α7 nAChRs)

Annals of Experimental and Molecular Biology, 2018
This themed section of the Annals of Experimental and Molecular Biology is the product of an article that is focusing on metabotropic signaling of an ionotropic channel alpha7 nicotinic ACh receptors (α7 nAChRs). The article talks about how α7 nAChR, being an ion channel, can function in a metabotropic-signaling mode via Gprotein coupling followed by ...
openaire   +1 more source

Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.

, 2009
The human alpha7 nicotinic acetylcholine receptor (nAChR) subunit and its Caenorhabditis elegans homolog, ACR-16, can generate functional recombinant homomeric receptors when expressed in Xenopus laevis oocytes.
Pienaar, Ilse, Buckingham, Steven D., Blundell, CD, Almond, A, Sattelle, Benedict M., Buckingham, SD, Matsuda, K, Sattelle, David B., Pienaar, IS, Kazuhiko Matsuda, Andrew K. Jones, Pienaar, I, Charles D. Blundell, Almond, Andrew; id_orcid, Matsuda, Kazuhiko, Akamatsu, M, Steven D. Buckingham, David B. Sattelle, Blundell, Charles D., Ilse Pienaar, Jones, AK, Akamatsu, Miki, Sattelle, DB, Andrew Almond, Miki Akamatsu, Almond, Andrew, Sattelle, BM, Benedict M. Sattelle, Jones, Andrew K.   +28 more
core   +1 more source

The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice.

, 2006
International audienceRATIONALE: Tobacco use is implicated in approximately 440,000 deaths per year, making it the leading cause of preventable death in the United States.
Brown, Sharon, Martin, Billy, Damaj, M. Imad, Walters, Carrie L., Changeux, Jean-Pierre   +4 more
core   +1 more source

Potentiation of cognitive enhancer effects of Alzheimer's disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task. [PDF]

Psychopharmacology (Berl), 2021
Bruszt N, Bali ZK, Tadepalli SA, Nagy LV, Hernádi I.   +4 more
europepmc   +1 more source

Heme-Oxygenase I and PCG-1α Regulate Mitochondrial Biogenesis via Microglial Activation of Alpha7 Nicotinic Acetylcholine Receptors Using PNU282987

, 2017
Aims: A loss in brain acetylcholine and cholinergic markers, subchronic inflammation, and impaired mitochondrial function, which lead to low-energy production and high oxidative stress, are common pathological factors in several neurodegenerative ...
García López, Manuela, Navarro González De Mesa, Elisa   +1 more
core   +1 more source

Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment

, 2008
The alpha7 nicotinic acetylcholine receptor (nAChR), a homopentameric, rapidly activating and desensitizing ligand-gated ion channel with relatively high degree of calcium permeability, is expressed in the mammalian central nervous system, including ...
Gubbins, Earl, Bertrand, Daniel, Li, Jinhe, Bertrand, Sonia, Cassar, Steven, Gopalakrishnan, M.   +5 more
core   +1 more source

Regulation of the activity of hippocampal stratum oriens interneurons by alpha 7 nicotinic acetylcholine receptors

, 2001
GABAergic interneurons have been shown to be a major target of cholinergic inputs to the hippocampus. Because these interneurons project to pyramidal neurons as well as other interneurons, activation of the cholinergic system is likely to produce a ...
Dunwiddie, Tom V., Buhler, Amber V.
core  

JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist.

, 2007
This report describes the in vitro features of a novel selective nicotinic acetylcholine receptor (nAChR) alpha7 agonist, JN403, (S)-(1-Aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid (S)-1-(2-fluoro-phenyl)-ethyl ester.
Lingenhoehl, Kurt, Hoyer, Daniel, Feuerbach, Dominik, Nozulak, Joachim, Mcallister, Kevin   +4 more
core