Results 101 to 110 of about 1,282,638 (192)

Cholinergic drugs inhibit in vitro megakaryopoiesis via the alpha7-nicotinic acetylcholine receptor

Platelets, 2011
Besides thrombopoietin several additional factors (i.e neurotransmitters and receptors) are known to be involved in the regulation of megakaryopoiesis at different stages. Recently, we identified functional α7 nicotinic acetylcholine receptors (nAChRα7) on platelets and megakaryocytic precursors. In platelets nAChRα7 form functional Ca(2+) channels and
Sophia, Thornton, Angelika, Schedel, Sabrina, Besenfelder, Harald, Klüter, Peter, Bugert   +4 more
openaire   +2 more sources

Opportunities in precision psychiatry using PET neuroimaging in psychosis

Neurobiology of Disease, 2019
With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that ...
Jennifer M. Coughlin, Andrew G. Horti, Martin G. Pomper   +2 more
doaj   +1 more source

α7 Nicotinic acetylcholine receptor-mediated anti-inflammatory effect in a chronic migraine rat model via the attenuation of glial cell activation

Journal of Pain Research, 2018
Qing Liu,1 Chaoyang Liu,1 Li Jiang,1 Maolin Li,1 Ting Long,1 Wei He,1 Guangcheng Qin,2 Lixue Chen,2 Jiying Zhou1 1Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China; 2Laboratory Research Center, The ...
Liu Q, Liu C, Jiang L, Li M, Long T, He W, Qin G, Chen L, Zhou J   +8 more
doaj  

Neuregulin-1 as a Context-Dependent Regulator of Neuroinflammation and Neural Repair: Mechanisms, Disease Relevance, and Therapeutic Challenges

Cells
Neuroinflammation is a coordinated response to central nervous system injury and disease involving resident glia, neurons, the neurovascular unit, and infiltrating immune cells.
Gregory D. Ford, Christopher McGinley, Oluwafayokemi Oyolola, Oyinkansola Adeyemi, Monique C. Surles-Zeigler, Shokofeh Rahimpour, Byron D. Ford   +6 more
doaj   +1 more source

Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases [PDF]

, 2005
Nicotine, a component of tobacco, is highly addictive but possesses beneficial properties such as cognitive improvements and memory maintenance. Involved in these processes is the neuronal nicotinic acetylcholine receptor (nAChR) alpha7, whose activation
Hoda, J. C., Huh, K H, Hoda, J C, Charpantier, E, Raggenbass, M, Allaman, Geraldine, Ogier, R, Raggenbass, Mario, Allaman, G, Charpantier, Eric, Fuhrer, Christian, Wiesner, A, Bertrand, Daniel, Wiesner, Andreas, Huh, K. H., Feuerbach, D, Ogier, Roch, Bertrand, D, Feuerbach, Dominik, Fuhrer, Christian; https://orcid.org/   +19 more
core   +1 more source

The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes

Neuroscience Letters, 1998
The rapid desensitization of alpha7 nicotinic acetylcholine receptors (nAChR) has presented a serious problem for the characterization of this receptor subtype, potentially confounding the interpretation of concentration-response relationships. However, the consistency of cell geometry and solution flow in oocyte recordings permits estimations of ...
Department of Pharmacology and Therapeutics, Box 100267 JHMHSC, University of Florida, Gainesville, FL 32610–0267, USA ( host institution ), Papke, Roger L ( author ), Thinschmidt, Jeffrey S ( author )   +2 more
openaire   +3 more sources

A Potential Role of Alpha-7 Nicotinic Acetylcholine Receptor in Cardiac Angiogenesis in a Pressure-Overload Rat Model

Journal of Pharmacological Sciences, 2010
.: This work investigated the expression of alpha-7 nicotinic acetylcholine receptor (α7nAChR) in the left ventricle and its putative role in cardiac angiogenesis in a pressure overload rat model induced by abdominal aorta coarctation. Blood pressure and
Min Ni, Zhong-Wei Yang, Dong-Jie Li, Quan Li, Shu-Hui Zhang, Ding-Feng Su, He-Hui Xie, Fu-Ming Shen   +7 more
doaj   +1 more source

Retinal ganglion cell neuroprotection induced by activation of alpha7 nicotinic acetylcholine receptors

Neural Regeneration Research, 2016
Glaucoma is a group of degenerative retinal diseases that damage the eye's optic nerve and can result in vision loss and blindness. It is characterized by optic neuropathy, cupping of the optic disk, and progressive loss of retinal ganglion cells (RGCs) and axons in the optic nerve.
openaire   +3 more sources

Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site. [PDF]

, 1995
Agrin is a basal lamina protein that induces aggregation of acetylcholine receptors (AChRs) and other molecules at the developing neuromuscular junction.
Ruegg, M. A., A J Denzer, Denzer, A J, M A Ruegg, Gesemann, M., M Gesemann, Gesemann, M, Ruegg, M A, Denzer, A. J.   +8 more
core   +1 more source

Nicotinic Acetylcholine Receptors are Possible Therapeutic Targets for Schizophrenia [PDF]

, 2010
The rate of smoking in patients with schizophrenia is higher than that in the general population. Nicotinic acetylcholine receptors (nAChR) are involved in the sensorimotor gating deficits in schizophrenia.
川崎, 博己, 荒木, 博陽, 45288, 45289, 鴻海, 俊太郎, 町支, 臣成, 45291, 末丸, 克矢, 45290, 日比野, 俐, 45293, 45292   +11 more
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