Results 1 to 10 of about 3,043 (112)

Adipose-derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2-mediated α7nAChR/NF-κB pathway. [PDF]

Animal Model Exp Med
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Dong M, Li W, Yang W, Ba T, Nan N, Liu Y, Han J, Hao H.   +7 more
europepmc   +2 more sources

α7nAChR alleviates cognitive impairment by promoting autophagy in astrocytes via CaMKK2/AMPK/mTOR pathway in sepsis-associated encephalopathy [PDF]

Frontiers in Immunology
BackgroundSepsis-associated encephalopathy (SAE) is a syndrome of cerebral dysfunction secondary to sepsis. Although the α7 nicotinic acetylcholine receptor (α7nAChR) plays a pivotal role in the SAE, the specific mechanisms by which it mediates ...
Yuesong Liu, Fuhua Wang, Lu Wang, Siqing Wang, Jinyan Xing   +4 more
doaj   +2 more sources

Diabetic Autonomic Neuropathy and Impaired Inflammatory Reflex [PDF]

Endocrinol Diabetes Metab
The cholinergic anti‐inflammatory pathway under normal and diabetic conditions. In the normal state, vagal activation through nicotinic acetylcholine receptors helps regulate immune responses and suppress excessive inflammation. In diabetes, impaired autonomic function and dysregulated cholinergic signalling weaken this anti‐inflammatory pathway ...
Dastmalchi N, Doustvandi M, Rahbarghazi R, Hajiasgharzadeh K.   +3 more
europepmc   +2 more sources

α7nAChR agonist GTS-21 ameliorates sepsis-induced acute kidney injury via MEF2/PGC-1α/HO-1 axis in mice. [PDF]

Clin Transl Med
This diagram illustrates opposing pathways regulating AKI (acute kidney injury). The left pathway shows LPS/TLR4 triggering mitochondrial damage (low MMP, Cyt C release, ROS) leading to apoptosis. The right pathway shows α7nAChR agonists activating MEF2 to upregulate PGC‐1α/HO‐1, promoting mitochondrial biogenesis and inhibiting injury, highlighting ...
Tang YJ, Liu HY, Li NQ, Zhang X, Lin YL, Zhang Y, Li Y, Deng JL, Yang PL, Meng QM, Tang YJ, Zhang ZY, Guan SH, Kang K, Wang HL, Gao Y.   +15 more
europepmc   +2 more sources

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies. [PDF]

Adv Sci (Weinh)
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Tang Q, Li J, Song H, Zhang A, Zeng H, Xu Y, Mo L, He J.   +7 more
europepmc   +2 more sources

The role of the α7 nicotinic acetylcholine receptor in promoting M2 macrophage polarization at inflammatory sites [PDF]

Scientific Reports
The α7 nicotinic acetylcholine receptor (α7nAChR) on macrophages exerts anti-inflammatory effects by suppressing the JAK/STAT and NF-κB pathways. Although the role of α7nAChR in immunoregulatory mechanisms in “individual” macrophages is established ...
Taiki Mihara, Hiroshi Tanabe, Yuma Nonoshita, Yuki Yamakawa, Tamaki Kurosawa, Masatoshi Hori   +5 more
doaj   +2 more sources

Curcumin regulates ferroptosis by activating α7 nicotinic acetylcholine receptor to improve sepsis-induced acute kidney injury [PDF]

Renal Failure
Acute kidney injury (AKI) is a frequent complication of sepsis. It has been reported that curcumin can alleviate sepsis-associated AKI (SA-AKI). This study aims to elucidate the regulatory effects and mechanisms of curcumin on ferroptosis in the context ...
Yongli Yang, Zhiying Xiao, Liangjin Liu, Tingting Hu, Yi Liu, Duan Wang   +5 more
doaj   +2 more sources

α7 Nicotinic Acetylcholine Receptor May Be a Pharmacological Target for Perioperative Neurocognitive Disorders

Frontiers in Pharmacology, 2022
Background: The α7 nicotinic acetylcholine receptor (α7nAChR) is a promising therapeutic target in neurodegenerative diseases. This study examined the effects of surgery and anesthesia on α7nAChR expression in the central nervous system and determined ...
Penghui Wei, Wenyuan Lyu, Lin Xu, Lin Xu, Hao Feng, Haipeng Zhou, Jianjun Li   +6 more
doaj   +1 more source

Nicotinic Acetylcholine Receptor Subunit Alpha-7 Mediates PD-L1 and CTLA-4 Expression in HepG2 Cells [PDF]

ImmunoAnalysis, 2021
Background: The liver is the largest solid organ in the body and has several unique immunological roles. The alpha7 subtype of nicotinic acetylcholine receptor (α7nAChR) is expressed in the liver and has different immunoregulatory effects.
Mina Afrashteh Nour, Fatemeh Kheradmand, Yousef Rasmi, Zahra Asadzadeh, Mohammad Amin Doustvandi, Mahdi Jafarlou, Khalil Hajiasgharzadeh, Behzad Baradaran   +7 more
doaj   +1 more source

Reduced size and macrophage content of advanced atherosclerotic lesions in mice with bone marrow specific deficiency of alpha 7 nicotinic acetylcholine receptor. [PDF]

PLoS ONE, 2015
In macrophages the α7 nicotinic acetylcholine receptor (α7nAChR) modulates production of inflammatory cytokines, cholesterol accumulation and lipoprotein uptake.
Robert H Lee, Guillermo Vazquez
doaj   +1 more source