Results 21 to 30 of about 3,518 (150)

Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection

Communications Biology, 2023
Activation of the cholinergic anti-inflammatory pathway (CAP) via vagus nerve stimulation has been shown to improve acute kidney injury in rodent models.
Yasuna Nakamura, Hirotaka Matsumoto, Chia-Hsien Wu, Daichi Fukaya, Rie Uni, Yosuke Hirakawa, Mikako Katagiri, Shintaro Yamada, Toshiyuki Ko, Seitaro Nomura, Youichiro Wada, Issei Komuro, Masaomi Nangaku, Reiko Inagi, Tsuyoshi Inoue   +14 more
doaj   +1 more source

Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent Meningitic Escherichia coli-Induced Blood–Brain Barrier Disruptions by Targeting the CISH/JAK2/STAT5b Axis

Biomedicines, 2022
Despite the availability of antibiotics over the last several decades, excessive antibiotic treatments for bacterial sepsis and meningitis (BSM) in children may result in several adverse outcomes.
Zelong Gong, Xuefeng Gao, Yubin Li, Jinhu Zou, Jingxian Lun, Jie Chen, Chengxing Zhou, Xiaolong He, Hong Cao   +8 more
doaj   +1 more source

Mechanisms underlying antidepressant effect of transcutaneous auricular vagus nerve stimulation on CUMS model rats based on hippocampal α7nAchR/NF-κB signal pathway

Journal of Neuroinflammation, 2021
Background Stress-induced neuroinflammation was considered to play a critical role in the pathogenesis of depression. Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from ...
Jun-ying Wang, Yue Zhang, Yu Chen, Yu Wang, Shao-yuan Li, Yi-fei Wang, Zi-xuan Zhang, Jinling Zhang, Peijing Rong   +8 more
doaj   +1 more source

Effect of Macrophage Expressed α7 Nicotinic Acetylcholine Receptor (α7nAChR) on Migration of Macrophages During Inflammation [PDF]

, 2023
Sepsis is a life-threatening condition characterized by overwhelming inflammation, resulting in organ system damage, leading to a high mortality rate. Care in the clinical setting is supportive, and there are no approved sepsis-specific treatments.
Keever, Kasey
core   +1 more source

Activation of α7 nicotinic acetylcholine receptor retards the development of endometriosis

Reproductive Biology and Endocrinology, 2022
Background Women with endometriosis have been shown to have a reduced vagal tone as compared with controls and vagotomy promoted while vagus nerve stimulation (VNS) decelerated the progression of endometriosis in mice.
Meihua Hao, Xishi Liu, Sun-Wei Guo
doaj   +1 more source

α7nAchR/NMDAR coupling affects NMDAR function and object recognition [PDF]

, 2018
The α7 nicotinic acetylcholine receptor (nAchR) and NMDA glutamate receptor (NMDAR) are both ligand-gated ion channels permeable to Ca2+ and Na+. Previous studies have demonstrated functional modulation of NMDARs by nAchRs, although the molecular ...
Roder, John C, Li, Shupeng, Nai, Qiang, Lipina, Tatiana V, Liu, Fang   +4 more
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Farnesyl Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking

Frontiers in Pharmacology, 2020
Inhibition of Ras farnesylation in acute has been found to upregulate the α7 nicotinic acetylcholine receptor (α7nAChR) activity. This study was carried out to investigate the effect of chronic administration for 7 days of farnesyl transferase inhibitor ...
Tingting Chen, Tingting Chen, Chengyun Cai, Lifeng Wang, Lifeng Wang, Shixin Li, Shixin Li, Ling Chen   +7 more
doaj   +1 more source

Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice. [PDF]

PLoS ONE, 2018
Clinical studies have shown that cigarette smoking is a dose-dependent and independent risk factor for acute pancreatitis. Cigarette smoke contains nicotine which can be converted to the potent receptor ligand and toxin, NNK [4-(methylnitrosamino)-1-(3 ...
A A Alahmari, B Sreekumar, V Patel, M Ashat, M Alexandre, A K Uduman, E O Akinbiyi, A Ceplenski, C A Shugrue, T R Kolodecik, N Tashkandi, S W Messenger, G E Groblewski, F S Gorelick, E C Thrower   +14 more
doaj   +1 more source

Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress

Redox Biology, 2018
Neointimal hyperplasia as a consequence of vascular injury is aggravated by inflammatory reaction and oxidative stress. The α7 nicotinic acetylcholine receptor (α7nAChR) is a orchestrator of cholinergic anti-inflammatory pathway (CAP), which refers to a ...
Dong-Jie Li, Hui Fu, Jie Tong, Yong-Hua Li, Le-Feng Qu, Pei Wang, Fu-Ming Shen   +6 more
doaj   +1 more source

Activation of α7nAChR by PNU282987 improves cognitive impairment through inhibiting oxidative stress and neuroinflammation in D-galactose induced aging via regulating α7nAChR/Nrf2/HO-1 signaling pathway

Experimental Gerontology, 2023
Aging is an important risk factor for neurodegenerative diseases. The activation of α7 nicotinic acetylcholine receptor (α7nAChR) is involved in inflammation and cognition, but the specific role it plays in aging remains unknown.
Yawen Zhang, Rui Ma, Wencheng Wang, Qian Deng, Chi Cao, Chunyang Yu, Shulin Li, Lei Shi, Jianying Tian   +8 more
doaj   +1 more source