Results 31 to 40 of about 3,518 (150)
Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats
BMC Cardiovascular Disorders, 2012 Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular diseases. The role of the alpha7 nicotinic acetylcholine receptor (α7nAChR) in inflammation has recently been identified.
Chen Ji-Kuai +5 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2017 Background The apolipoprotein E ε4 (APOE4) genotype is a prominent late-onset Alzheimer’s disease (AD) risk factor. ApoE4 disrupts memory function in rodents and may contribute to both plaque and tangle formation.
Hoau-Yan Wang +14 more
doaj +1 more source
, 2021 The cholinergic anti-inflammatory pathway (CAIP) has been proposed to regulate gastrointestinal inflammation via acetylcholine released from the vagus nerve activating α7 nicotinic receptor (α7nAChR) on macrophages.
Xiao-Yan Feng (7254674) +9 more
core +1 more source
The role of alpha-7 nicotinic receptors in food intake behaviors
Frontiers in Psychology, 2014 Nicotine alters appetite and energy expenditure, leading to changes in body weight. While the exact mechanisms underlying these effects are not fully established, both central and peripheral involvement of the alpha-7 nicotinic acetylcholine receptor ...
Kristina L. McFadden +3 more
doaj +1 more source
, 2021 Recently, we reported that nicotine plays a role in the failure of the macrophage in the clearance of Mycobacterium avium subspecies paratuberculosis (MAP) during infection in Crohn’s disease smokers.
Ebraheem Naser +2 more
core +1 more source
Molecular Medicine, 2022 Background Inflammatory bowel disease (IBD) is a common chronic remitting disease with no satisfactory treatment. The aim of this study was to investigate the protective effect of α7 nicotinic acetylcholine receptor (α7nAChR), and to determine the ...
Wenyuan Pu +9 more
doaj +1 more source
The Alpha 7 Nicotinic Acetylcholine Receptor Does Not Affect Neonatal Brain Injury
Biomedicines, 2022 Inflammation plays a central role in the development of neonatal brain injury. The alpha 7 nicotinic acetylcholine receptor (α7nAChR) can modulate inflammation and has shown promising results as a treatment target in rodent models of adult brain injury ...
Maria E. Hammarlund +10 more
doaj +1 more source
Neuronal and Glial α7 Nicotinic Acetylcholine Receptors: Role in Alzheimer’s Disease Pathophysiology
LifeCholinergic projections from the basal forebrain to the cortex and hippocampus play a critical role in cognitive functions, many of which rely on signaling through the alpha7 nicotinic acetylcholine receptor (α7nAChR).
Kerry Rennie
doaj +1 more source
Immunohistochemical expression of CD11b and α7nAChR in the spleen. A)
, 2013 Spleens harvested 6 hours after heat stress were stained for CD11b (green) and α7nAChR (blue). The open arrowheads indicate CD11b-positive cells expressing α7nAChR, and the closed arrowheads indicate CD11b-positive cells without expression of α7nAChR ...
Junya Shimazaki (284145) +9 more
core +1 more source
Frontiers in Pharmacology, 2021 The cholinergic anti-inflammatory pathway (CAIP) has been proposed to regulate gastrointestinal inflammation via acetylcholine released from the vagus nerve activating α7 nicotinic receptor (α7nAChR) on macrophages.
Li Zhou +10 more
doaj +1 more source