Results 11 to 20 of about 3,518 (150)
Electroacupuncture Alleviate Lung Injury of Sepsis Through α7nAChR and NF-κB Signaling Pathway
Intensive Care Research, 2022 Background Sepsis is the leading cause of death in hospitalized patients in the intensive care unit (ICU). Although substantial progress has been made in studies on the treatment of sepsis, the mortality rate remains extremely high.
Xingxing Shi +6 more
doaj +2 more sources
Role of α7nAChR-NMDAR in sevoflurane-induced memory deficits in the developing rat hippocampus. [PDF]
PLoS ONE, 2018 Detrimental effects of volatile anaesthetics, including sevoflurane, on the structure and function of the developing brain have been reported. The internalization of N-methyl-D-aspartate receptors (NMDARs) contributes to anaesthetic neurotoxicity.
XiaoHong Tang +7 more
doaj +2 more sources
Redox Biology, 2023 The potential coexistence of Alzheimer's disease (AD) and atrial fibrillation (AF) is increasingly common as aging-related diseases. However, little is known about mechanisms responsible for atrial remodeling in AD pathogenesis.
Jikai Zhao +8 more
doaj +2 more sources
Cellular Physiology and Biochemistry, 2018 Backgrund/Aims: To investigate the effects of activated α7 nicotinic acetylcholine receptor (α7nAChR) on postoperative cognitive dysfunction (POCD) and intestinal injury induced by cardiopulmonary bypass (CPB) and its relationship with the Th17 response ...
Keyan Chen +8 more
doaj +3 more sources
α7nAChR on B cells directs T cell differentiation to prevent viral myocarditis
JCI InsightPatients with viral myocarditis (VMC) exhibit evident autonomic nervous system imbalance, and adverse cardiac remodeling is involved in impaired cholinergic function. The α7 nicotinic acetylcholine receptor (α7nAChR), which is a neurotransmitter receptor,
Jing Lu +6 more
doaj +2 more sources
Disrupting the α7nAChR–NR2A protein complex exerts antidepressant-like effects [PDF]
, 2021 Major depressive disorder (MDD) is associated with significant morbidity and mortality. Most antidepressant medications target the serotonin and norepinephrine transporters, but a significant minority of patients do not respond to treatment and novel ...
Su, Ping +9 more
core +1 more source
, 2023 A deficiency of the functional α7 nicotinic acetylcholine receptor (α7nAChR) impairs neuronal and immune systems. The SARS-CoV-2 spike protein (S12) facilitates virus cell entry during COVID-19 infection and can also independently disrupt cellular ...
Jonathan A. Coleman (14494784) +11 more
core +2 more sources
Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization
, 2023 The α7 nicotinic acetylcholine receptor (α7nAChR) mediates signaling in the central nervous system and cholinergic anti-inflammatory pathways. Ivermectin is a positive allosteric modulator of a full-length α7nAChR and an agonist of the α7nAChR construct ...
Nandan Haloi (14670453) +8 more
core +2 more sources
Effects of kynurenic acid and choline on lipopolysaccharide-induced cyclooxygenase pathway
Türk Biyokimya Dergisi, 2023 Inflammation can be endogenously modulated by the cholinergic anti-inflammatory pathway via calcium (Ca2+)-permeable alpha-7 nicotinic acetylcholine receptor (α7nAChR) ion channel expressed in immune cells.
Baris Elif +4 more
doaj +1 more source
Vagal α7nAChR signaling regulates α7nAChR+Sca1+ cells during lung injury repair
Stem Cell Research & Therapy, 2020 Background The distal airways of the lung and bone marrow are innervated by the vagus nerve. Vagal α7nAChR signaling plays a key role in regulating lung infection and inflammation; however, whether this pathway regulates α7nAChR+Sca1+ cells during lung ...
Xiaoyan Chen +3 more
doaj +1 more source