The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay [PDF]
Frontiers in Neuroscience, 2023 The magnitude of innate inflammatory immune responses is dependent on interactions between peripheral neural and immune cells. In particular, a cholinergic anti-inflammatory pathway (CAP) has been identified in the spleen whereby noradrenaline (NA ...
Thomas Simon +16 more
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Pharmacological and Electroceutical Targeting of the Cholinergic Anti-Inflammatory Pathway in Autoimmune Diseases [PDF]
Pharmaceuticals, 2023 Continuous dialogue between the immune system and the brain plays a key homeostatic role in various immune responses to environmental cues. Several functions are under the control of the vagus nerve-based inflammatory reflex, a physiological mechanism ...
Moncef Zouali
doaj +6 more sources
Cholinergic anti-inflammatory pathway and COVID-19 [PDF]
BioImpacts, 2022 The cholinergic anti-inflammatory pathway (CAP) first described by Wang et al, 2003 has contemporary interest arising from the COVID-19 pandemic. While tobacco smoking has been considered an aggravating factor in the severity of COVID-19 infections, it ...
Danial Mehranfard, Robert C. Speth
doaj +6 more sources
Role of Cholinergic Anti-Inflammatory Pathway in Protecting Sepsis-Induced Acute Lung Injury through Regulation of the Conventional Dendritic Cells [PDF]
Mediators of Inflammation, 2022 Background. The cholinergic anti-inflammatory pathway connects the immune response system and the nervous system via the vagus nerve. The key regulatory receptor is the α7-subtype of the nicotinic acetylcholine receptor (α7nAChR).
Ruiting Li +11 more
doaj +4 more sources
Cholinergic Anti-Inflammatory Pathway and the Liver [PDF]
Advanced Pharmaceutical Bulletin, 2017 The hepatic vagus branches innervate the liver and serve an important role in liver-brain connection. It appears that brain modulates inflammatory responses by activation of vagal efferent fibers.
Khalil Hajiasgharzadeh, Behzad Baradaran
doaj +5 more sources
Evidence of upregulation of the cholinergic anti-inflammatory pathway in late-life depression. [PDF]
J Affect Disord, 2021 Decreased cholinergic tone associated with increased proinflammatory cytokines has been observed in several human diseases associated with low-grade inflammation. We examined if this attenuated cholinergic anti-inflammatory pathway (CAP) mechanism contributed to increased neuroinflammation observed in depression.We measured cerebrospinal fluid (CSF ...
Pomara N +9 more
europepmc +9 more sources
The brain-liver cholinergic anti-inflammatory pathway and viral infections [PDF]
Bioelectronic Medicine, 2023 Efferent cholinergic signaling is a critical and targetable source of immunoregulation. The vagus nerve (VN) is the primary source of cholinergic signaling in the body, and partially innervates hepatic functionality through the liver-brain axis.
Samuel Martínez-Meza +4 more
doaj +4 more sources
The role of the cholinergic anti‐inflammatory pathway in autoimmune rheumatic diseases [PDF]
Scandinavian Journal of Immunology, 2021 AbstractThe cholinergic anti‐inflammatory pathway (CAP) is a classic neuroimmune pathway, consisting of the vagus nerve, acetylcholine (ACh)—the pivotal neurotransmitter of the vagus nerve—and its receptors. This pathway can activate and regulate the activities of immune cells, inhibit cell proliferation and differentiation, as well as suppress ...
Jiaqi Lv, Xiaoxiao Ji, Huiqin Hao
exaly +4 more sources
The cholinergic anti-inflammatory pathway alleviates acute lung injury [PDF]
Molecular Medicine, 2020 The ubiquiotous nuclear protein HMGB1 is extracellularly released by dying cells or activated innate immunity cells to promote inflammation. Extracellular HMGB1 plays a prominent role in the pathogenesis of acute lung injury of infectious as well as ...
Ulf Andersson
doaj +5 more sources
RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation. [PDF]
Int Immunopharmacol, 2020 Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels having many functions including inflammation control, as part of the cholinergic anti-inflammatory pathway. Genome wide association studies implicated RIC3, a chaperone of nAChRs, in multiple sclerosis (MS), a neuroinflammatory disease.
Ben-David Y +10 more
europepmc +4 more sources