Results 41 to 50 of about 3,652,668 (207)

The cholinergic anti-inflammatory pathway meets microRNA [PDF]

Cell Research, 2013
Acetylcholine is a cellular mediator selected early in evolution as a key neurotransmitter, but its other biological roles including immune-modulation remain to be elucidated. In a recent paper published in Cell Research, Sun et al. report that acetylcholine modulates cytokine production in macrophages via microRNA-124.
openaire   +2 more sources

COVID-19-related myocarditis and cholinergic anti-inflammatory pathways

Hellenic Journal of Cardiology, 2021
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2, is currently in a pandemic outbreak and has become a global health issue. In addition to the primarily involvement of the respiratory system, myocarditis is considered an important and fatal lesion in patients with COVID-19.
Liu, Weike, Liu, Zhendong, Li, Yue-Chun
openaire   +4 more sources

Noninvasive ultrasound stimulation to treat myocarditis through splenic neuro-immune regulation

Journal of Neuroinflammation, 2023
Background The cholinergic anti-inflammatory pathway (CAP) has been widely studied to modulate the immune response. Current stimulating strategies are invasive or imprecise.
Tianshu Liu, Yanan Fu, Jiawei Shi, Shukun He, Dandan Chen, Wenqu Li, Yihan Chen, Li Zhang, Qing Lv, Yali Yang, Qiaofeng Jin, Jing Wang, Mingxing Xie   +12 more
doaj   +1 more source

Ultrasonic Stimulation of the Cholinergic Anti-Inflammatory Pathway for Renal Protection [PDF]

Journal of the American Society of Nephrology, 2013
AKI encompasses a large spectrum of pathophysiological processes starting from the early reversible proximal tubular lesion to the definite loss of glomerular filtration and even death. Even discrete AKI ( i.e.
Hougardy, Jean-Michel, Sadis, Claude, Le Moine, Alain   +2 more
openaire   +3 more sources

MOLECULAR MECHANISMS REGULATING LPS-INDUCED INFLAMMATION IN THE BRAIN

Frontiers in Molecular Neuroscience, 2016
Neuro-inflammation, one of the pathogenic causes of neurodegenerative diseases, is regulated through the cholinergic anti-inflammatory pathway via the 7 nicotinic acetylcholine receptor (7 nAChR).
Olena eLykhmus, Nibha eMishra, Lyudmyla eKoval, Olena eKalashnyk, Galyna eGergalova, Kateryna eUspenska, Serghiy eKomisarenko, Hermona eSoreq, Maryna eSkok   +8 more
doaj   +1 more source

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, Bernd L., Aderogba, Mutalib A., Okorji, Uchechukwu P., Okorji, U. P., Fiebich, B.L., Olajide, Olumayokun A.   +6 more
core   +1 more source

Presentation_1_The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay.pdf

, 2023
The magnitude of innate inflammatory immune responses is dependent on interactions between peripheral neural and immune cells. In particular, a cholinergic anti-inflammatory pathway (CAP) has been identified in the spleen whereby noradrenaline (NA ...
Matteo Donegá (15288079), Margriet J. Vervoordeldonk (12890930), Thomas Simon (81007), Nikola Dolezalova (10489334), Justin Perkins (12722243), Arun Sridhar (8900048), Sandrine Hugues (15288073), Alexandre Bondue (15288067), Philippe Blancou (199052), Nicolas Glaichenhaus (239803), Mélanie Guyot (14916051), Eric Macia (15288076), Nicolas Hypolite (15243095), Julien Lavergne (15288070), Clara Panzolini (15243092), Kourosh Saeb-Parsy (7205267), Joseph Kirk (10489331)   +16 more
core   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19

Frontiers in Physiology, 2021
The renin angiotensin system and the cholinergic anti-inflammatory pathway have been recently shown to modulate lung inflammation in patients with COVID-19.
Martina Di Maro, Mauro Cataldi, Mariarosaria Santillo, Martina Chiurazzi, Simona Damiano, Barbara De Conno, Antonio Colantuoni, Bruna Guida   +7 more
doaj   +1 more source